Over the past decade, mitochondria have emerged as critical integrators of energy
production, generation of reactive oxygen species (ROS), multiple cell death, and signaling …

The highly regulated processes of mitochondrial fusion (joining), fission (division) and
trafficking, collectively called mitochondrial dynamics, determine cell-type specific …

A number of observations have shown that mitochondria are at the center of the
pathophysiology of the failing heart and mitochondrial-based oxidative stress (OS) …

Cardiac mitochondria, the main source of energy as well as free radicals, are vital
organelles for normal functioning of the heart. Mitochondrial number, structure, turnover and …

Abstract Purpose of Review We review therapeutic approaches aimed at restoring function
of the failing heart by targeting mitochondrial reactive oxygen species (ROS), ion handling …

Cardiovascular disease is a major leading cause of morbidity and mortality in the United
States and elsewhere. Alterations in mitochondrial function are increasingly being …

The mitochondrion serves a critical role as a platform for energy transduction, signaling, and
cell death pathways relevant to common diseases of the myocardium such as heart failure …

Heart failure is a pressing worldwide public-health problem with millions of patients having
worsening heart failure. Despite all the available therapies, the condition carries a very poor …

The mitochondria are mostly abundant in the heart, a beating organ of high-energy
demands. Their function extends beyond being a power plant of the cell including redox …

The ATP consumption in heart is very intensive to support muscle contraction and relaxation.
Mitochondrion is the power plant of the cell. Mitochondrial dysfunction has long been …