TET1 protein is reported to suppress cancer invasion and metastasis in prostate and breast
cancer while EZH2, a polycomb group protein, has been identified as an oncogene in many …

Abstract Ten-Eleven Translocation 1 (TET1) is a member of ten eleven translocation
enzymes, which convert 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC). TET1 …

Background Abnormal DNA methylation/demethylation is recognized as a hallmark of
cancer. TET (ten-eleven translocation) family members are novel DNA demethylation related …

The development of chemo‐resistance impairs the outcome of the first line platinum‐based
chemotherapies for ovarian cancer. Deregulation of DNA methylation/demethylation …

DNA methylation and demethylation play a critical role in the regulation of the molecular
pathogenesis of gliomas. Tet methylcytosine dioxygenase 1 (TET1) catalyses the sequential …

DNA demethylases of the TET family function as tumor suppressors in various human
cancers, but their pathogenic contributions and mechanisms of action in gastric …

Background Ten-eleven translocation 1 (TET1) is a dioxygenase that converts 5-
methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) to induce DNA demethylation …

Objective Ten-eleven translocation (TET) enzymes that oxidize a 5-methylcytosine (5mC) to
yield 5-hydroxymethylcytosine (5hmC) have been responsible for fine-tuning methylation …

Abstract Epithelial-Mesenchymal Transition (EMT) is a critical step in the progression of
cancer. Malignant melanoma, a cancer developed from pigmented melanocytes …

Renal carcinoma is the most common type of kidney cancer in adults and is responsible for~
90‑95% of the cases of kidney cancer. Ten‑eleven translocation methylcytosine …