Phosphorylation of ATXN1 at Ser776 in the cerebellum
ND Jorgensen, JM Andresen, S Lagalwar… - Journal of …, 2009 - Wiley Online Library
Abstract Spinocerebellar ataxia type 1 (SCA1) is one of nine inherited neurodegenerative
disorders caused by a mutant protein with an expanded polyglutamine tract …
disorders caused by a mutant protein with an expanded polyglutamine tract …
[HTML][HTML] SCA1-like disease in mice expressing wild-type ataxin-1 with a serine to aspartic acid replacement at residue 776
L Duvick, J Barnes, B Ebner, S Agrawal, M Andresen… - Neuron, 2010 - cell.com
Glutamine tract expansion triggers nine neurodegenerative diseases by conferring toxic
properties to the mutant protein. In SCA1, phosphorylation of ATXN1 at Ser776 is thought to …
properties to the mutant protein. In SCA1, phosphorylation of ATXN1 at Ser776 is thought to …
Hsp70/Hsc70 regulates the effect phosphorylation has on stabilizing ataxin‐1
ND Jorgensen, JM Andresen, JE Pitt… - Journal of …, 2007 - Wiley Online Library
Abstract Spinocerebellar ataxia type 1 (SCA1) is an inherited neurodegenerative disorder.
The mutation causing SCA1 is an expansion in the polyglutamine tract of the ATXN1 protein …
The mutation causing SCA1 is an expansion in the polyglutamine tract of the ATXN1 protein …
Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination
I Schmitt, M Linden, H Khazneh, BO Evert… - Biochemical and …, 2007 - Elsevier
Spinocerebellar ataxia type 3 is a neurodegenerative disease caused by expansion of a
polyglutamine domain in the protein ataxin-3 (ATXN3). Physiological functions of ATXN3 …
polyglutamine domain in the protein ataxin-3 (ATXN3). Physiological functions of ATXN3 …
[HTML][HTML] Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model
JMP Ortiz, N Mollema, N Toker, CJ Adamski… - Neurobiology of …, 2018 - Elsevier
Abstract Spinocerebellar ataxia type 1 (SCA1) is a polyglutamine (polyQ) repeat
neurodegenerative disease in which a primary site of pathogenesis are cerebellar Purkinje …
neurodegenerative disease in which a primary site of pathogenesis are cerebellar Purkinje …
[HTML][HTML] Loss of the Spinocerebellar Ataxia type 3 disease protein ATXN3 alters transcription of multiple signal transduction pathways
Spinocerebellar ataxia type 3 (SCA3) is a dominantly inherited neurodegenerative disorder
caused by a polyglutamine-encoding CAG repeat expansion in the ATXN3 gene which …
caused by a polyglutamine-encoding CAG repeat expansion in the ATXN3 gene which …
Beyond the glutamine expansion: influence of posttranslational modifications of ataxin-1 in the pathogenesis of spinocerebellar ataxia type 1
H Ju, H Kokubu, J Lim - Molecular neurobiology, 2014 - Springer
Posttranslational modifications are crucial mechanisms that modulate various cellular
signaling pathways, and their dysregulation is associated with many human diseases …
signaling pathways, and their dysregulation is associated with many human diseases …
[HTML][HTML] Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis
Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative disease
caused by expansion of a CAG repeat that encodes a polyglutamine tract in ATAXIN1 …
caused by expansion of a CAG repeat that encodes a polyglutamine tract in ATAXIN1 …
Partial loss of Tip60 slows mid-stage neurodegeneration in a spinocerebellar ataxia type 1 (SCA1) mouse model
KM Gehrking, JM Andresen, L Duvick… - Human molecular …, 2011 - academic.oup.com
Abstract Spinocerebellar ataxia type 1 (SCA1) is one of nine dominantly inherited
neurodegenerative diseases caused by polyglutamine tract expansion. In SCA1, the …
neurodegenerative diseases caused by polyglutamine tract expansion. In SCA1, the …
[HTML][HTML] Identification of a novel phosphorylation site in ataxin-1
Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurodegenerative disease
resulting from an expanded CAG repeat in the SCA1 gene that leads to an expanded …
resulting from an expanded CAG repeat in the SCA1 gene that leads to an expanded …