The ability to target specific sequences of DNA through oligonucleotide-based triple-helix
formation provides a powerful tool for genetic manipulation. Under experimental conditions …

DNA structure is a critical element in determining its function. The DNA molecule is capable
of adopting a variety of non-canonical structures, including three-stranded (ie triplex) …

The ability to specifically manipulate gene expression has wide‐ranging applications in
experimental biology and in gene‐based therapeutics. The design of molecules that …

Oligonucleotides offer enormous potential for manipulating gene function in cells and, as
such, constitute a promising new class of pharmaceutical agents. Oligonucleotides that form …

Triplex-forming oligonucleotides (TFOs) can bind to polypurine/polypyrimidine regions in
DNA in a sequence-specific manner. The specificity of this binding raises the possibility of …

DNA is a strikingly flexible molecule and can form a variety of secondary structures,
including the triple helix, which is the subject of this review. The DNA triplex may be formed …

Triplex-forming oligonucleotides constitute an interesting DNA sequence-specific tool that
can be used to target cleaving or cross-linking agents, transcription factors or nucleases to a …

The design of specific DNA ligands is an important challenge in biological and biomedical
sciences. Targeting the source of genetic information may allow highly efficient gene …

Recognition of B-DNA by oligonucleotides that form triple helices is a unique method to
specifically recognize sequences of double-stranded DNA. Recently, some significant …

Triplex technology offers a useful approach for site-specific modification of gene structure
and function both in vitro and in vivo. Triplex-forming oligonucleotides (TFOs) bind to their …