In large amounts, alcohol and its metabolites can overwhelm the gastrointestinal tract (GI)
and liver and lead to damage both within the GI and in other organs. Specifically, alcohol …

Alcohol abuse is a significant contributor to the global burden of disease and can lead to
tissue damage and organ dysfunction in a subset of alcoholics. However, a subset of …

The excessive use of alcohol is a global problem causing many adverse pathological health
effects and a significant financial health care burden. This review addresses the effect of …

Alcohol is inextricably linked with the digestive system. It is absorbed through the gut and
metabolised by hepatocytes within the liver. Excessive alcohol use results in alterations to …

Excessive alcohol intake is a leading cause of morbidity and mortality worldwide.
Perspective of alcohol-associated disease development is shifting, from the traditional …

Chronic inflammation is often associated with alcohol-related medical conditions. The key
inducer of such inflammation, and also the best understood, is gut microflora-derived …

Frank Burr Mallory's landmark observation in 1911 on the histopathology of alcoholic liver
disease (ALD) was the first identification of a link between inflammation and ALD. In this …

Alcoholic liver disease (ALD) has been among the leading causes of cirrhosis and liver-
related death worldwide for decades. Early discoveries in alcoholic liver disease identified …

In recent years, some new processes have been proposed to explain how alcohol may
influence behavior, psychological symptoms and alcohol seeking in alcohol-dependent …

Background The end-organ effects of alcohol span throughout the entire body, from the
gastrointestinal tract to the central nervous system (CNS). In the intestine, alcohol use …