Cocaine, amphetamine, and methamphetamine abuse disorders are serious worldwide
health problems. To date, there are no FDA-approved medications for the treatment of these …

The development of new treatments for substance use disorders requires identification of
targetable molecular mechanisms. Pathology in glutamatergic neurotransmission system in …

Glutamate transmission is an important mediator of the development of substance use
disorders, particularly with regard to relapse. The present review summarizes the changes in …

Individuals addicted to drugs of abuse such as alcohol, nicotine, cocaine, and heroin are a
significant burden on healthcare systems all over the world. The positive reinforcing …

Well-developed cellular mechanisms exist to preserve glutamate homeostasis and regulate
extrasynaptic glutamate levels. Accumulating evidence indicates that disruptions in …

Post-translational covalent modifications of glutamate receptors remain a hot topic. Early
studies have established that this family of receptors, including almost all ionotropic and …

Cortico-striatal glutamate transmission has been implicated in both the initiation and
expression of addiction related behaviors, such as locomotor sensitization and drug …

Cocaine use disorder is a chronically relapsing disease without FDA-approved treatments.
Using a rodent model of cocaine relapse, we and others have previously demonstrated that …

All addictive drugs facilitate dopamine transmission, and determining the role of dopamine
has been the predominant focus of biomedical research in addiction for 20 years. Newer …

Dopamine–glutamate co-release is a unique property of midbrain neurons primarily located
in the ventral tegmental area (VTA). Dopamine neurons of the VTA are important for …