Evolutionary and functional classification of the CARF domain superfamily, key sensors in prokaryotic antivirus defense
KS Makarova, A Timinskas, YI Wolf… - Nucleic acids …, 2020 - academic.oup.com
Abstract CRISPR-associated Rossmann Fold (CARF) and S MODS-a ssociated and fused to
v arious e ffector d omains (SAVED) are key components of c yclic oligonucleotide-b ased a …
v arious e ffector d omains (SAVED) are key components of c yclic oligonucleotide-b ased a …
Structural basis of CRISPR-Cas Type III prokaryotic defence systems
R Molina, N Sofos, G Montoya - Current opinion in structural biology, 2020 - Elsevier
Highlights•Type III is the most diverse and complex CRISPR-Cas system.•Type III CRISPR-
Cas systems cleave RNA and DNA.•The effector complexes generate secondary …
Cas systems cleave RNA and DNA.•The effector complexes generate secondary …
Type III CRISPR-Cas: beyond the Cas10 effector complex
G Stella, L Marraffini - Trends in Biochemical Sciences, 2023 - cell.com
Abstract Type III CRISPR-Cas loci encode some of the most abundant, yet complex, immune
systems of prokaryotes. They are composed of a Cas10 complex that uses an RNA guide to …
systems of prokaryotes. They are composed of a Cas10 complex that uses an RNA guide to …
Specificity and sensitivity of an RNA targeting type III CRISPR complex coupled with a NucC endonuclease effector
S Grüschow, CS Adamson, MF White - Nucleic acids research, 2021 - academic.oup.com
Type III CRISPR systems detect invading RNA, resulting in the activation of the enzymatic
Cas10 subunit. The Cas10 cyclase domain generates cyclic oligoadenylate (cOA) second …
Cas10 subunit. The Cas10 cyclase domain generates cyclic oligoadenylate (cOA) second …
Structure-based functional mechanisms and biotechnology applications of anti-CRISPR proteins
CRISPR loci and Cas proteins provide adaptive immunity in prokaryotes against invading
bacteriophages and plasmids. In response, bacteriophages have evolved a broad spectrum …
bacteriophages and plasmids. In response, bacteriophages have evolved a broad spectrum …
[HTML][HTML] Antiviral type III CRISPR signalling via conjugation of ATP and SAM
CRISPR systems are widespread in the prokaryotic world, providing adaptive immunity
against mobile genetic elements,. Type III CRISPR systems, with the signature gene cas10 …
against mobile genetic elements,. Type III CRISPR systems, with the signature gene cas10 …
Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate
SA McMahon, W Zhu, S Graham, R Rambo… - Nature …, 2020 - nature.com
The CRISPR system provides adaptive immunity against mobile genetic elements in
prokaryotes. On binding invading RNA species, Type III CRISPR systems generate cyclic …
prokaryotes. On binding invading RNA species, Type III CRISPR systems generate cyclic …
Regulation of the RNA and DNA nuclease activities required for Pyrococcus furiosus Type III-B CRISPR–Cas immunity
K Foster, S Grüschow, S Bailey, MF White… - Nucleic acids …, 2020 - academic.oup.com
Abstract Type III CRISPR–Cas prokaryotic immune systems provide anti-viral and anti-
plasmid immunity via a dual mechanism of RNA and DNA destruction. Upon target RNA …
plasmid immunity via a dual mechanism of RNA and DNA destruction. Upon target RNA …
The diverse arsenal of type III CRISPR–Cas-associated CARF and SAVED effectors
JA Steens, CRP Salazar… - Biochemical Society …, 2022 - portlandpress.com
Type III CRISPR–Cas systems make use of a multi-subunit effector complex to target foreign
(m) RNA transcripts complementary to the guide/CRISPR RNA (crRNA). Base-pairing of the …
(m) RNA transcripts complementary to the guide/CRISPR RNA (crRNA). Base-pairing of the …
DNA and RNA interference mechanisms by CRISPR-Cas surveillance complexes
A Plagens, H Richter, E Charpentier… - FEMS microbiology …, 2015 - academic.oup.com
The CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-
associated) adaptive immune systems use small guide RNAs, the CRISPR RNAs (crRNAs) …
associated) adaptive immune systems use small guide RNAs, the CRISPR RNAs (crRNAs) …