Protein inhibitors of CRISPR-Cas9
J Bondy-Denomy - ACS chemical biology, 2018 - ACS Publications
Bacteria are under constant predation from viruses, called bacteriophages (phages). This
threat has driven the evolution of multiple defense systems, including the CRISPR-Cas …
threat has driven the evolution of multiple defense systems, including the CRISPR-Cas …
The basic building blocks and evolution of CRISPR–Cas systems
KS Makarova, YI Wolf, EV Koonin - Biochemical Society …, 2013 - portlandpress.com
CRISPR (clustered regularly interspaced short palindromic repeats)–Cas (CRISPR-
associated) is an adaptive immunity system in bacteria and archaea that functions via a …
associated) is an adaptive immunity system in bacteria and archaea that functions via a …
The Card1 nuclease provides defence during type III CRISPR immunity
In the type III CRISPR–Cas immune response of prokaryotes, infection triggers the
production of cyclic oligoadenylates that bind and activate proteins that contain a CARF …
production of cyclic oligoadenylates that bind and activate proteins that contain a CARF …
[HTML][HTML] CRISPR–Cas: complex functional networks and multiple roles beyond adaptive immunity
CRISPR–Cas is a prokaryotic adaptive immune system that functions by incorporating
fragments of foreign DNA into CRISPR arrays. The arrays containing spacers derived from …
fragments of foreign DNA into CRISPR arrays. The arrays containing spacers derived from …
[HTML][HTML] Structural rearrangements allow nucleic acid discrimination by type ID Cascade
CRISPR-Cas systems are adaptive immune systems that protect prokaryotes from foreign
nucleic acids, such as bacteriophages. Two of the most prevalent CRISPR-Cas systems …
nucleic acids, such as bacteriophages. Two of the most prevalent CRISPR-Cas systems …
Characterization and repurposing of type I and type II CRISPR–Cas systems in bacteria
CRISPR–Cas systems constitute the adaptive immune system of bacteria and archaea, as a
sequence-specific nucleic acid targeting defense mechanism. The sequence-specific …
sequence-specific nucleic acid targeting defense mechanism. The sequence-specific …
[PDF][PDF] Structure and mechanism of a cyclic trinucleotide-activated bacterial endonuclease mediating bacteriophage immunity
Bacteria possess an array of defenses against foreign invaders, including a broadly
distributed bacteriophage defense system termed CBASS (cyclic oligonucleotide-based anti …
distributed bacteriophage defense system termed CBASS (cyclic oligonucleotide-based anti …
[PDF][PDF] DNA unwinding is the primary determinant of CRISPR-Cas9 activity
Bacterial adaptive immunity utilizes RNA-guided surveillance complexes comprising Cas
proteins together with CRISPR RNAs (crRNAs) to target foreign nucleic acids for destruction …
proteins together with CRISPR RNAs (crRNAs) to target foreign nucleic acids for destruction …
[PDF][PDF] Cas5d protein processes pre-crRNA and assembles into a cascade-like interference complex in subtype IC/Dvulg CRISPR-Cas system
Clustered regularly interspaced short palindromic repeats (CRISPRs), together with an
operon of CRISPR-associated (Cas) proteins, form an RNA-based prokaryotic immune …
operon of CRISPR-associated (Cas) proteins, form an RNA-based prokaryotic immune …
Three CRISPR-Cas immune effector complexes coexist in Pyrococcus furiosus
CRISPR-Cas immune systems function to defend prokaryotes against potentially harmful
mobile genetic elements including viruses and plasmids. The multiple CRISPR-Cas systems …
mobile genetic elements including viruses and plasmids. The multiple CRISPR-Cas systems …