The insides of cells can be viewed as a treasure trove of targets for therapeutic intervention
of diseases or as deposits for contrasting agents. Increasingly the molecules that need to be …

The cell membrane poses a substantial hurdle to the use of pharmacologically active
biomacromolecules that are not per se actively translocated into cells. An appealing …

The cell membrane is a highly selective barrier. This limits the cellular uptake of molecules
including DNA, oligonucleotides, peptides and proteins used as therapeutic agents …

During the last decade, cell-penetrating peptides have been investigated for their ability to
overcome the plasma membrane barrier of mammalian cells for the intracellular or …

Cell-penetrating peptides (CPPs) are short peptides of less than 30 amino acids that are
able to penetrate cell membranes and translocate different cargoes into cells. The only …

Cell penetrating peptides, generally categorized as amphipathic or cationic depending on
their sequence, are increasingly drawing attention as a non-invasive delivery technology for …

A major thrust in the biomedical and pharmaceutical industries is to develop diagnostic and
therapeutic tools that have significantly improved selectivity and specificity compared to the …

In 1988, two unrelated papers reported the discovery of peptide vectors with innate cell
translocation properties, setting the ground for a new area of research that over the years …

Cell penetrating peptides (CPPs) can deliver cell-impermeable therapeutic cargos into cells.
In particular, CPP-cargo conjugates tend to accumulate inside cells by endocytosis …

The recent discovery of new potent therapeutic molecules that do not reach the clinic due to
poor delivery and low bioavailability have made of delivery a key stone in therapeutic …