In a large proportion of individuals nervous system damage may lead to a debilitating
chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder …

Chronic pain can occur after peripheral nerve injury, infection, or inflammation. Under such
neuropathic pain conditions, sensory processing in the affected body region becomes …

This review examines recently recognized roles of immunological processes in pain
modulation and explores the potential implications of these immunologically derived …

Background Acute pain is a warning mechanism that exists to prevent tissue damage,
however pain can outlast its protective purpose and persist beyond injury, becoming …

Neuro-immune interactions contribute to the pathogenesis of neuropathic pain due to
peripheral nerve injury. A large body of preclinical evidence supports the idea that the …

Neuropathic pain refers to a variety of chronic pain conditions with differing underlying
pathophysiologic mechanisms and origins. Recent studies indicate a communication …

Cytotoxicity and consequent cell death pathways are a critical component of the immune
response to infection, disease or injury. While numerous examples of inflammation causing …

Tissue damage, inflammation or injury of the nervous system may result in chronic
neuropathic pain characterised by increased sensitivity to painful stimuli (hyperalgesia), the …

One area that has emerged as a promising therapeutic target for the treatment and
prevention of chronic pain and opioid tolerance/hyperalgesia is the modulation of the central …

Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …