Genetics of congenital heart disease: the contribution of the noncoding regulatory genome

AV Postma, CR Bezzina, VM Christoffels - Journal of human genetics, 2016 - nature.com
Congenital heart disease (CHD) is the most common type of birth defect. The advent of
corrective cardiac surgery and the increase in knowledge concerning the longitudinal care …

Genetics and genomics of congenital heart disease

S Zaidi, M Brueckner - Circulation research, 2017 - Am Heart Assoc
Congenital heart disease is the most common birth defect, and because of major advances
in medical and surgical management, there are now more adults living with congenital heart …

Genetic basis of human congenital heart disease

SN Nees, WK Chung - Cold Spring Harbor perspectives …, 2020 - cshperspectives.cshlp.org
Congenital heart disease (CHD) is the most common major congenital anomaly with an
incidence of∼ 1% of live births and is a significant cause of birth defect–related mortality …

[HTML][HTML] Genetics of congenital heart disease: a narrative review of recent advances and clinical implications

J Yasuhara, V Garg - Translational Pediatrics, 2021 - ncbi.nlm.nih.gov
Congenital heart disease (CHD) is the most common human birth defect and remains a
leading cause of mortality in childhood. Although advances in clinical management have …

Genetic contribution to congenital heart disease (CHD)

NA Shabana, SU Shahid, U Irfan - Pediatric cardiology, 2020 - Springer
Congenital heart defects (CHD) are the most common congenital problems in neonates. The
basis for CHD is multifactorial, involving genetic and environmental components. The …

Genomic frontiers in congenital heart disease

SU Morton, D Quiat, JG Seidman… - Nature Reviews …, 2022 - nature.com
The application of next-generation sequencing to study congenital heart disease (CHD) is
increasingly providing new insights into the causes and mechanisms of this prevalent birth …

The molecular genetics of congenital heart disease: a review of recent developments

M Wolf, CT Basson - Current Opinion in Cardiology, 2010 - journals.lww.com
The recent developments in the genetics of congenital heart disease are reviewed. In many
cases, it is the novel interactions of previously known genes that highlight this year's …

Molecular genetic mechanisms of congenital heart disease

TZ Choudhury, V Garg - Current opinion in genetics & development, 2022 - Elsevier
Congenital heart disease (CHD) affects~ 1% of all live births, but a definitive etiology is
identified in only~ 50%. The causes include chromosomal aneuploidies and copy-number …

Molecular genetics and complex inheritance of congenital heart disease

NS Diab, S Barish, W Dong, S Zhao, G Allington, X Yu… - Genes, 2021 - mdpi.com
Congenital heart disease (CHD) is the most common congenital malformation and the
leading cause of mortality therein. Genetic etiologies contribute to an estimated 90% of CHD …

Genetics of congenital heart disease

JJ Edwards, BD Gelb - Current opinion in cardiology, 2016 - journals.lww.com
Recent technological advances have rapidly expanded our understanding of CHD genetics,
and support the applicability to the clinical domain in both sporadic and inherited disease …