Safety evaluation through genotoxicity and apoptotic markers following RISUG® induced contraception and its reversal in male rabbits

AS Ansari, A Badar, NK Lohiya - Reproductive Toxicology, 2018 - Elsevier
The safety evaluation following vas occlusion with RISUG® and its reversal with DMSO and
NaHCO 3, using genotoxicity tests and apoptotic marker assays, was carried out in rabbits …

Evaluation of genotoxicity in leukocytes and testis following intra-vasal contraception with RISUG and its reversal by DMSO and NaHCO3 in Wistar albino rats

AS Ansari, I Alam, M Hussain, SR Khan… - Reproductive Toxicology, 2013 - Elsevier
Evaluation of genotoxicity of RISUG®–a vas based contraceptive, was carried out in the
present study. Animals were allotted into groups of sham operated control, vas occlusion …

Toxicity and mutagenicity evaluation following RISUG contraception reversal in rats

AS Ansari, M Hussain, SR Khan… - International …, 2018 - journals.sagepub.com
Reestablishment of fertility, after a male contraceptive method, is of great concern. In this
context, RISUG (Reversible Inhibition of Sperm Under Guidance) has been evaluated for its …

Studies on biochemical, oxidative and genotoxicity alterations following vas blockage with reversible inhibition of sperm under guidance and reversal in rats

AS Ansari, M Hussain, SR Khan, A Badar… - Indian Journal of …, 2022 - journals.lww.com
OBJECTIVE: To evaluate the biochemical and genotoxicity at the level of reactive oxygen
species (ROS) following vas occlusion with RISUG and its reversal by Dimethyl sulphoxide …

Relative suitability of DMSO and NaHCO3 for reversal of RISUG® induced long‐term contraception

AS Ansari, M Hussain, SR Khan, NK Lohiya - Andrology, 2016 - Wiley Online Library
Among the vas‐based methods on trial, reversible inhibition of sperm under guidance
(RISUG®), a co‐polymer of styrene and maleic anhydride is being projected as an effective …

[PDF][PDF] RISUG® offers early contraception: an experience during phase III clinical trials

NK Lohiya, AS Ansari, TC Sadasukhi… - J Reprod Healthc …, 2022 - researchgate.net
Objectives: An early contraceptive efficacy with reasonable assurance of reversibility has
been a challenge in male contraception. With nearly four decades of research in reversible …

Contraception with RISUG® and functional reversal through DMSO and NaHCO3 in male rabbits

AS Ansari, A Badar, K Balasubramanian… - Asian journal of …, 2017 - journals.lww.com
The study aimed to evaluate reversal of short-and long-term vas occlusion with reversible
inhibition of sperm under guidance (RISUG) using dimethyl sulfoxide (DMSO) and sodium …

Sperm characteristics and teratology in rats following vas deferens occlusion with RISUG and its reversal

NK Lohiya, R Suthar, A Khandelwal… - … journal of andrology, 2010 - Wiley Online Library
The functional success of the reversal of vas occlusion by styrene maleic anhydride
(RISUG), using the solvent vehicle, Dimethyl Sulphoxide (DMSO), has been investigated …

RISUG: An intravasal injectable male contraceptive

NK Lohiya, I Alam, M Hussain, SR Khan… - Indian Journal of …, 2014 - journals.lww.com
Over the last two decades RISUG has been drawing attention in the field of male
contraception. It promises to sterile men for a period of up to 10-15 years. According to …

[HTML][HTML] Reversible inhibition of sperm under guidance as an intratubular and reversible contraception in female rats: An experimental study

AS Ansari, K Sevliya, A Badar… - International journal of …, 2021 - ncbi.nlm.nih.gov
Objective An exploratory study was conducted with a concept of non-invasive, transcervical,
single-intervention and reversible contraception using RISUGⓇ in females. Materials and …