Visceral adiposity in obesity causes excessive free fatty acid (FFA) flux into the liver via the
portal vein and may cause fatty liver disease and hepatic insulin resistance. However …

We previously demonstrated that an aspalathin-enriched green rooibos extract (GRE)
reversed palmitate-induced insulin resistance in C2C12 skeletal muscle and 3T3-L1 fat cells …

Type 2 diabetes mellitus (T2DM)-induced cardiomyopathy is associated with cardiac
oxidative stress, inflammation, and remodeling. Sulforaphane (SFN), an isothiocyanate …

Aims/hypothesis Arctigenin is a natural compound that had never been previously
demonstrated to have a glucose-lowering effect. Here it was found to activate AMP-activated …

Background AMP-activated protein kinase (AMPK), particularly AMPKα2 isoform, plays a
critical role in maintaining cardiac homeostasis. It was reported that sulforaphane (SFN) …

Background/objectives The current study was designed to investigate the protective role of
salisroside on rats through the study of energy metabolism homeostasis and inflammation …

Scope Normal physiological processes require a robust biological timer called the circadian
clock. Dysregulation of circadian rhythms contributes to a variety of metabolic syndrome …

Arachidonic acid (AA, a proinflammatory fatty acid) in combination with iron promotes excess
reactive oxygen species (ROS) production and exerts a deleterious effect on mitochondria …

Type 2 diabetes is characterized by insulin resistance in target tissues and hyperglycemia.
Catalpol is a natural product isolated from the root of Rehmannia glutinosa, which has been …

Purpose Although several researches have demonstrated that rooibos extract has
hypoglycemic effect, the role of aspalathin, a main polyphenol in the extract, remains …