Certain limitations of the neurosphere assay (NSA) have resulted in a search for alternative
culture techniques for brain tumor-initiating cells (TICs). Recently, reports have described …

Cancer stem cells may mediate therapy resistance and recurrence in various types of
cancer, including glioblastoma. Cancer stemlike cells can be isolated from long-term cancer …

Renewable neurosphere formation in culture is a defining characteristic of certain brain
tumor initiating cells. This retrospective study was designed to assess the relationship …

Gliomas are highly invasive tumors and the pronounced invasive features of gliomas
prevent radical surgical resection. In the search for new therapeutics targeting invasive …

Glioblastomas are the most lethal primary brain tumor that frequently relapse or progress as
focal masses after radiation, suggesting that a fraction of tumor cells are responsible for the …

Glioblastomas, the most common and aggressive form of astrocytoma, are refractory to
therapy, and molecularly heterogeneous. The ability to establish cell cultures that preserve …

In addition to the primary culturing of cancer stem cells (CSCs) from tumor tissues, CSCs are
found in established tumor cell lines. However, it is unclear how culture conditions affect …

Background Multicellular spheroids, an appropriate in vitro system for simulating 3-D tumor
micro-milieu can be used for evaluating and predicting tumor response to therapeutic agents …

Purpose: Glioblastoma spheroid cultures are enriched in tumor stem-like cells and therefore
may be more representative of the respective primary tumors than conventional monolayer …

Object Brain tumor stem cells (TSCs) hypothetically drive the malignant phenotype of
glioblastoma multiforme (GBM), and evidence suggests that a better understanding of these …