The three-dimensional structure of chromatin plays a crucial role in development and
disease, both of which are associated with transcriptional changes. However, given the …

Higher-order chromatin structure is emerging as an important regulator of gene expression.
Although dynamic chromatin structures have been identified in the genome, the full scope of …

Nuclei are central hubs for information processing in eukaryotic cells. The need to fit large
genomes into small nuclei imposes severe restrictions on genome organization and the …

Much progress has been made recently in single-cell chromosome conformation capture
technologies. However, a method that allows simultaneous profiling of chromatin …

The 3D organization of chromatin regulates many genome functions. Our understanding of
3D genome organization requires tools to directly visualize chromatin conformation in its …

The genomic organization of chromatin is increasingly recognized as a key regulator of cell
behavior, but deciphering its regulation mechanisms requires detailed knowledge of …

Whereas folding of genomes at the large scale of epigenomic compartments and
topologically associating domains (TADs) is now relatively well understood, how chromatin …

Dynamic three-dimensional chromatin conformation is a critical mechanism for gene
regulation during development and disease. Despite this, profiling of three-dimensional …

Cell differentiation and function are regulated across multiple layers of gene regulation,
including modulation of gene expression by changes in chromatin accessibility. However …

Three-dimensional (3D) chromatin organization plays a key role in regulating mammalian
genome function; however, many of its physical features at the single-cell level remain …