Context: Mutations in BRAF are rare in the follicular variant of papillary thyroid carcinoma
(FV-PTC). Objective: We identified and functionally characterized a novel T599I-VKSR (600 …

To assess the mutational status of BRAF in FVPTC, we directly sequenced the genomic DNA
of 30 primary FVPTC samples. BRAF mutations were found in only 4 (13%) tumors. We also …

Activating mutations of the BRAF gene are the most common genetic alterations in papillary
thyroid carcinomas (PTCs) and the T1799A transversion, resulting in BRAF V600E …

Introduction Activating mutations of the BRAF oncogene are frequently detected in papillary
thyroid carcinoma (PTC) and have been associated with a worse prognosis. The amino acid …

An activating mutation in the BRAF gene is the most common genetic alteration in papillary
thyroid carcinomas (PTCs). The mutation in PTCs is almost a c. 1799T> A transversion …

Activating mutations of BRAF have been identified in a variety of human cancers, most
notably melanomas and papillary thyroid carcinomas (PTCs). The aim of the present study …

Background: Papillary thyroid carcinoma (PTC) is the most common malignant tumor of the
thyroid gland, accounting for 74–80% of all thyroid cancers. The 1799T> A transversion is an …

Activating mutations in the BRAF kinase gene have recently been reported in human
cancers. The aim of the present study was to determine the frequency of BRAF mutations in …

Genetic alteration is the driving force for thyroid tumorigenesis and progression, based upon
which novel approaches to the management of thyroid cancer can be developed. A recent …

BRAF exon 15 mutations are the most common molecular alterations found in papillary
thyroid carcinoma (PTC). To date, there is no information regarding BRAF alterations in the …