Genome-wide association studies of atrial fibrillation: past, present, and future

MF Sinner, PT Ellinor, T Meitinger… - Cardiovascular …, 2011 - academic.oup.com
Genome-wide association studies (GWAS) for atrial fibrillation (AF) have identified three
distinct genetic loci on chromosomes 1q21, 4q25, and 16q22 that are associated with the …

Common variation in atrial fibrillation: navigating the path from genetic association to mechanism

NR Tucker, S Clauss, PT Ellinor - Cardiovascular research, 2016 - academic.oup.com
Atrial fibrillation (AF) is the most common cardiac arrhythmia with well-established clinical
and genetic risk components. Genome-wide association studies (GWAS) have identified 17 …

Emerging directions in the genetics of atrial fibrillation

NR Tucker, PT Ellinor - Circulation research, 2014 - Am Heart Assoc
Atrial fibrillation (AF) is the most common arrhythmia and is associated with increased
morbidity. As the population ages and the prevalence of AF continues to rise, the …

New advances in the genetic basis of atrial fibrillation

S Mahida, PT Ellinor - Journal of cardiovascular …, 2012 - Wiley Online Library
New Genetic Loci for Atrial Fibrillation. Over the past decade, compelling evidence has
emerged from population‐based studies to suggest that AF is a heritable disease. More …

Multi-ethnic genome-wide association study for atrial fibrillation

C Roselli, MD Chaffin, LC Weng, S Aeschbacher… - Nature …, 2018 - nature.com
Atrial fibrillation (AF) affects more than 33 million individuals worldwide and has a complex
heritability. We conducted the largest meta-analysis of genome-wide association studies …

Meta-analysis identifies six new susceptibility loci for atrial fibrillation

PT Ellinor, KL Lunetta, CM Albert, NL Glazer… - Nature …, 2012 - nature.com
Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart
failure and death. We conducted a genome-wide association study (GWAS) in individuals of …

Genomic basis of atrial fibrillation

A Bapat, CD Anderson, PT Ellinor, SA Lubitz - Heart, 2018 - heart.bmj.com
Atrial fibrillation (AF) is a prevalent arrhythmia associated with substantial morbidity,
mortality and costs. Available management strategies generally have limited efficacy and …

Genetics of atrial fibrillation in 2020: GWAS, genome sequencing, polygenic risk, and beyond

C Roselli, M Rienstra, PT Ellinor - Circulation research, 2020 - Am Heart Assoc
Atrial fibrillation is a common heart rhythm disorder that leads to an increased risk for stroke
and heart failure. Atrial fibrillation is a complex disease with both environmental and genetic …

Common variants for atrial fibrillation: results from genome-wide association studies

X Liu, F Wang, AC Knight, J Zhao, J Xiao - Human genetics, 2012 - Springer
Atrial fibrillation (AF) affects more than 5 million people worldwide; however, none of the anti-
arrhythmic drugs available now are entirely optimal in terms of efficacy and safety. A better …

Genetic variants associated with susceptibility to atrial fibrillation in a Japanese population

L Liu, Y Ebana, J Nitta, Y Takahashi, S Miyazaki… - Canadian Journal of …, 2017 - Elsevier
Background Atrial fibrillation (AF) affects millions of individuals worldwide. The genome-
wide association studies have identified robust genetic associations with AF. Methods We …