Environmental enrichment increases glucocorticoid receptors and decreases GluA2 and protein kinase M zeta (PKMζ) trafficking during chronic stress: a protective …

RM Zanca, SH Braren, B Maloney… - Frontiers in behavioral …, 2015 - frontiersin.org
Environmental enrichment (EE) housing paradigms have long been shown beneficial for
brain function involving neural growth and activity, learning and memory capacity, and for …

Increase of glucocorticoid receptor expression after environmental enrichment: relations to spatial memory, exploration and anxiety-related behaviors

P Sampedro-Piquero, A Begega, JL Arias - Physiology & behavior, 2014 - Elsevier
Environmental enrichment (EE) produces a remarkable degree of structural and functional
plasticity in the hippocampus and possible mediators of these changes, such as …

Environmental enrichment enhances sociability by regulating glutamate signaling pathway through GR by epigenetic mechanisms in amygdala of Indian field mice …

SE Jeyaraj, K Sivasangari, J García-Colunga… - General and …, 2021 - Elsevier
Environmental enrichment (EE) dynamically regulates gene expression and synaptic
plasticity with positive consequences on behavior. The present study was performed on field …

[HTML][HTML] Mineralocorticoid receptor and glucocorticoid receptor work alone and together in cell-type-specific manner: Implications for resilience prediction and targeted …

NP Daskalakis, OC Meijer, ER de Kloet - Neurobiology of stress, 2022 - Elsevier
Abstract 'You can't roll the clock back and reverse the effects of experiences' Bruce McEwen
used to say when explaining how allostasis labels the adaptive process. Here we will for …

Long-lasting behavioral responses to stress involve a direct interaction of glucocorticoid receptors with ERK1/2–MSK1–Elk-1 signaling

M Gutièrrez-Mecinas, AF Trollope… - Proceedings of the …, 2011 - National Acad Sciences
Stressful events are known to have a long-term impact on future behavioral stress
responses. Previous studies suggested that both glucocorticoid hormones and glutamate …

The MAPK pathway and Egr-1 mediate stress-related behavioral effects of glucocorticoids

JM Revest, F Di Blasi, P Kitchener, F Rougé-Pont… - Nature …, 2005 - nature.com
Many of the behavioral consequences of stress are mediated by the activation of the
glucocorticoid receptor by stress-induced high levels of glucocorticoid hormones. To explore …

Epigenetic mechanisms in stress and adaptation

KR Mifsud, M Gutièrrez-Mecinas, AF Trollope… - Brain, behavior, and …, 2011 - Elsevier
Epigenetic mechanisms are processes at the level of the chromatin that control the
expression of genes but their role in neuro-immuno-endocrine communication is poorly …

Differential impact of stress and environmental enrichment on corticolimbic circuits

MA Smail, BL Smith, N Nawreen, JP Herman - … biochemistry and behavior, 2020 - Elsevier
Stress exposure can produce profound changes in physiology and behavior that can impair
health and well-being. Of note, stress exposure is linked to anxiety disorders and depression …

Environmental enrichment protects against stress-induced anxiety: Role of glucocorticoid receptor, ERK, and CREB signaling in the basolateral amygdala

LS Novaes, NB Dos Santos, RFP Batalhote… - …, 2017 - Elsevier
Environmental enrichment (EE) is an experimental animal model that enhances an animal's
opportunity to interact with sensory, motor, and social stimuli, compared to standard …

Making memories of stressful events: a journey along epigenetic, gene transcription, and signaling pathways

JMHM Reul - Frontiers in psychiatry, 2014 - frontiersin.org
Strong psychologically stressful events are known to have a long-lasting impact on behavior.
The consolidation of such, largely adaptive, behavioral responses to stressful events …