Molecular and Genetic Basis of Pathogenesis in Francisella Tularensis

JR Barker, KE Klose - Annals of the New York Academy of …, 2007 - Wiley Online Library
The genetic means of pathogenesis of Francisella tularensis are poorly understood. F.
tularensis is able to survive and replicate within macrophages, and a virulence factor, MglA …

The unraveling panoply of Francisella tularensis virulence attributes

KL Meibom, A Charbit - Current opinion in microbiology, 2010 - Elsevier
Francisella tularensis is a highly infectious Gram-negative bacterium causing the zoonotic
disease tularemia. This facultative intracellular pathogen multiplies in vivo mainly inside …

Francisella tularensis: unravelling the secrets of an intracellular pathogen

PCF Oyston - Journal of medical microbiology, 2008 - microbiologyresearch.org
Francisella tularensis has been recognized as the causative agent of tularaemia for almost a
century. Since its discovery in 1911, it has been shown to infect a wide range of hosts …

Working toward the Future: Insights into Francisella tularensis Pathogenesis and Vaccine Development

RD Pechous, TR McCarthy… - … and molecular biology …, 2009 - Am Soc Microbiol
Francisella tularensis is a facultative intracellular gram-negative pathogen and the
etiological agent of the zoonotic disease tularemia. Recent advances in the field of …

A Francisella tularensis Pathogenicity Island Required for Intramacrophage Growth

FE Nano, N Zhang, SC Cowley, KE Klose… - Journal of …, 2004 - Am Soc Microbiol
Francisella tularensis is a gram-negative, facultative intracellular pathogen that causes the
highly infectious zoonotic disease tularemia. We have discovered a ca. 30-kb pathogenicity …

Will the enigma of Francisella tularensis virulence soon be solved?

RW Titball, A Johansson, M Forsman - Trends in microbiology, 2003 - cell.com
Francisella tularensis is one of the most infectious bacterial pathogens known and is the
causative agent of the zoonotic disease tularemia. In spite of the importance of this pathogen …

Virulence determinants and protective antigens of Francisella tularensis

A Sjöstedt - Current opinion in microbiology, 2003 - Elsevier
Very little is known about virulence mechanisms of the highly virulent bacterium Francisella
tularensis. Specific genetic features of F. tularensis have been obstacles for the …

Loops and networks in control of Francisella tularensis virulence

KL Meibom, M Barel, A Charbit - Future Microbiology, 2009 - Future Medicine
Francisella tularensis is a highly infectious, Gram-negative bacterium responsible for the
disease tularemia in a broad variety of animals, including humans. F. tularensis intracellular …

Identification of MglA-Regulated Genes Reveals Novel Virulence Factors in Francisella tularensis

A Brotcke, DS Weiss, CC Kim, P Chain… - Infection and …, 2006 - Am Soc Microbiol
The facultative intracellular bacterium Francisella tularensis causes the zoonotic disease
tularemia. F. tularensis resides within host macrophages in vivo, and this ability is essential …

Modulation of virulence factors in Francisella tularensis determines human macrophage responses

PE Carlson Jr, JA Carroll, DM O'Dee, GJ Nau - Microbial pathogenesis, 2007 - Elsevier
Francisella tularensis, the causative agent of tularemia and Category A biodefense agent, is
known to replicate within host macrophages, though the pathogenesis of this organism is …