Addressing current medical needs in invasive fungal infection prevention and treatment with new antifungal agents, strategies and formulations

SK Pitman, RH Drew, JR Perfect - Expert opinion on emerging …, 2011 - Taylor & Francis
Introduction: Morbidity and mortality associated with invasive fungal infections (IFIs) remains
unacceptably high. Such diseases represent a substantial burden to the healthcare system …

New facets of antifungal therapy

YL Chang, SJ Yu, J Heitman, M Wellington, YL Chen - Virulence, 2017 - Taylor & Francis
Invasive fungal infections remain a major cause of morbidity and mortality in
immunocompromised patients, and such infections are a substantial burden to healthcare …

New and investigational triazole agents for the treatment of invasive fungal infections

A De Sarro, E La Camera, MT Fera - Journal of Chemotherapy, 2008 - Taylor & Francis
The incidence of invasive fungal infections (IFIs) caused by both common and uncommon
opportunistic fungi is increasing along with emerging fungal resistance. Since traditional …

[HTML][HTML] Antifungal resistance and the role of new therapeutic agents

A Logan, A Wolfe, JC Williamson - Current Infectious Disease Reports, 2022 - Springer
Abstract Purpose of Review Advances in health care over time have led to an evolution in
the epidemiology of invasive fungal infections. There is an increasing concern for antifungal …

Recent advances and challenges in the treatment of invasive fungal infections

PL Shao, LM Huang, PR Hsueh - International journal of antimicrobial …, 2007 - Elsevier
The frequency of invasive fungal infections (IFIs) has increased over the last decade with the
rise in at-risk populations of patients. The morbidity and mortality of IFIs are high and …

How urgent is the need for new antifungals?

AG Stewart, DL Paterson - Expert Opinion on Pharmacotherapy, 2021 - Taylor & Francis
Introduction: Invasive fungal infection carries a high morbidity, mortality and economic cost.
In recent times, a rising incidence of fungal infection and antifungal resistance is occurring …

Innovative therapies for invasive fungal infections in preclinical and clinical development

Y Yu, K Albrecht, J Groll, A Beilhack - Expert Opinion on …, 2020 - Taylor & Francis
Introduction The incidence of life-threatening invasive fungal infections (IFIs) has increased
significantly in recent years. Current therapeutic options for IFIs are limited. Only four major …

[HTML][HTML] Current antimycotics, new prospects, and future approaches to antifungal therapy

G Wall, JL Lopez-Ribot - Antibiotics, 2020 - mdpi.com
Fungal infections represent an increasing threat to a growing number of immune-and
medically compromised patients. Fungi are eukaryotic organisms and, as such, there is a …

[HTML][HTML] Aspiring antifungals: review of current antifungal pipeline developments

TJ Gintjee, MA Donnelley, GR Thompson III - Journal of Fungi, 2020 - mdpi.com
Invasive fungal infections are associated with significant morbidity and mortality, and their
management is restricted to a variety of agents from five established classes of antifungal …

Antifungal therapy in invasive fungal infections

SCA Chen, EG Playford, TC Sorrell - Current opinion in pharmacology, 2010 - Elsevier
Early treatment of invasive fungal infections (IFIs) is essential for optimal clinical outcomes.
Standard antifungal drugs (polyenes, azoles and echinocandins) are not predictably …