Nitric oxide: a new messenger in the brain

J Bruhwyler, E Chleide, JF Liégeois… - … & Biobehavioral Reviews, 1993 - Elsevier
The important role played by nitric oxide (NO) in the central nervous system has largely
been emphasized in the recent literature. It can originate at least from four different sources …

Sub-cellular targeting of constitutive NOS in health and disease

YH Zhang, B Casadei - Journal of molecular and cellular cardiology, 2012 - Elsevier
Constitutive nitric oxide synthases (NOSs) are ubiquitous enzymes that play a pivotal role in
the regulation of myocardial function in health and disease. The discovery of both a …

Mechanisms of cell signaling by nitric oxide and peroxynitrite: from mitochondria to MAP kinases

AL Levonen, RP Patel, P Brookes, YM Go… - … and Redox Signaling, 2001 - liebertpub.com
Many of the biological and pathological effects of nitric oxide (NO) are mediated through cell
signaling pathways that are initiated by NO reacting with metalloproteins. More recently, it …

Nitric oxide in the central nervous system

I Paakkari, P Lindsberg - Annals of medicine, 1995 - Taylor & Francis
The majority of the data on nitric oxide (NO) in the central nervous system (CNS) relies on
histochemical and immunesohistochemical evidence concerning the distribution of the nitric …

Neuronal nitric oxide synthase regulates basal microvascular tone in humans in vivo

MD Seddon, PJ Chowienczyk, SE Brett, B Casadei… - Circulation, 2008 - Am Heart Assoc
Background—Nitric oxide (NO) has a pivotal role in the regulation of vascular tone and
blood flow, with dysfunctional release contributing to disease pathophysiology. These effects …

Pharmacological strategies for the regulation of inducible nitric oxide synthase: neurodegenerative versus neuroprotective mechanisms

R Pannu, I Singh - Neurochemistry international, 2006 - Elsevier
Inducible nitric oxide synthase (iNOS) is one of three NOS isoforms generating nitric oxide
(NO) by the conversion of l-arginine to l-citrulline. iNOS has been found to be a major …

Nitric oxide synthase inhibition in healthy adults reduces regional and total cerebral macrovascular blood flow and microvascular perfusion

KJ Carter, AT Ward, JM Kellawan… - The Journal of …, 2021 - Wiley Online Library
The importance of nitric oxide (NO) in regulating cerebral blood flow (CBF) remains
unresolved, due in part to methodological approaches, which lack a comprehensive …

[HTML][HTML] Nitric oxide—Important messenger in human body

A Martina, P Jana, S Anna, B Tomas - Open journal of molecular and …, 2012 - scirp.org
General idea of this comprehensive review is to summarize information about the role of
nitric oxide in the human body—cardiovascular, respiratory, urgenital, gut, NO and immune …

Nitric oxide control of cardiac function: is neuronal nitric oxide synthase a key component?

CE Sears, EA Ashley… - … Transactions of the …, 2004 - royalsocietypublishing.org
Nitric oxide (NO) has been shown to regulate cardiac function, both in physiological
conditions and in disease states. However, several aspects of NO signalling in the …

[HTML][HTML] Significance of nitric oxide synthases: Lessons from triple nitric oxide synthases null mice

M Tsutsui, A Tanimoto, M Tamura, H Mukae… - Journal of …, 2015 - Elsevier
Nitric oxide (NO) is synthesized by three distinct NO synthases (neuronal, inducible, and
endothelial NOSs), all of which are expressed in almost all tissues and organs in humans …