Functional interactions between G protein-coupled receptors (GPCRs) are widely reported
whereas the mechanisms underlying these interactions remain unclear. A rapidly growing …

The ATP-gated K+ channel openers diazoxide, levcromakalim and morphine induce cell
hyperpolarization by opening the K+ channels and enhancing K+ efflux. This …

1. The actions of opioids on synaptic transmission in rat periaqueductal grey (PAG)
neurones were examined using whole‐cell patch‐clamp recordings in brain slices. 2 …

The opioid peptide met-enkephalin (met-ENK) produces an outward current with an
increase in input conductance in locus coeruleus (LC) neurons. This current has been …

Agonists at alpha 2-adrenoceptors, delta-opioid receptors, and somatostatin receptors were
applied to dissociated guinea pig submucous plexus neurons; whole-cell recordings of …

Kim, Chang-Ju, Jeong-Seop Rhee, and Norio Akaike. Modulation of high-voltage activated
Ca2+ channels in the rat periaqueductal gray neurons by μ-type opioid agonist. J …

To clarify the effects of opioid peptides, and in particular the effects of kappa‐receptor
agonists on the activity of supraoptic neurons, extracellular recordings were made from 71 …

Opioid peptides have profound inhibitory effects on the production of oxytocin and
vasopressin, but their direct effects on magnocellular neuroendocrine neurons appear to be …

Key point• I h is a hyperpolarisation‐activated current that influences neuronal excitability
and is present in some sensory neurons.• The magnitude and properties of Ih in different …

μ-Opioid receptors (MORs) activate G-protein coupled inwardly rectifying potassium (GIRK)
channels. The peptide agonist [d-Ala2, NMe-Phe4, Gly5-ol] enkephalin (DAMGO), but not …