Pneumonic plague, an often-fatal disease for which no vaccine is presently available, results
from pulmonary infection by the bacterium Yersinia pestis. The Y. pestis V protein is a …

Vaccination with live attenuated Yersinia pestis confers protection against pneumonic
plague but is not considered safe for general use. Subunit plague vaccines containing the Y …

Septic bacterial pneumonias are a major cause of death worldwide. Several of the highest
priority bioterror concerns, including anthrax, tularemia, and plague, are caused by bacteria …

Cell contact by the plague bacterium Yersinia pestis initiates the injection of several
virulence factors that target biochemical pathways critical for host clearance of bacteria …

Yersinia pestis (Yp)-one of the world's most deadly human pathogens-is the gram-negative
bacterium that causes pneumonic plague. Virulent antibiotic-resistant Yp strains exist and …

V antigen of Yersinia pestis is a multifunctional protein that has been implicated as a
protective antigen, a virulence factor, and a regulatory protein. A series of V-antigen …

Pulmonary infection with the bacterium Yersinia pestis causes pneumonic plague, an often-
fatal disease for which no vaccine is presently available. Antibody-mediated humoral …

Yersinia pestis causes pneumonic plague, an exceptionally virulent disease for which we
lack a safe and effective vaccine. Antibodies specific for the Y. pestis F1 and LcrV proteins …

Vaccinating with live, conditionally attenuated, pigmentation (Pgm)-deficient Yersinia pestis
primes T cells that protect mice against pneumonic plague. However, Pgm-deficient strains …

The purified recombinant V antigen from Yersinia pestis, expressed in Escherichia coli and
adsorbed to aluminum hydroxide, an adjuvant approved for human use, was used to …