The field of modern embryo culture spans several decades. However, in the last decade of
the 20th century a resurgence of interest in embryo physiology and metabolism led to highly …

Publisher Summary During the preimplantation period of mammalian embryo development,
the conceptus undergoes significant changes in its physiology, metabolism, and genetic …

There are several treatises on the composition of embryo culture media and the role of
specific medium components in supporting mammalian embryo development in vitro (1–3). It …

Methods for the culture of preimplantation human embryos evolved primarily from those
used for mouse embryos. The initial method was usually culture in a single medium in …

Abstract Development of preimplantation embryos, from fertilization to hatched-blastocyst
stage, has been a challenging task, regardless of the mammalian species being studied …

Despite advantages of in vitro embryo production in many species, widespread use of this
technology is limited by generally lower developmental competence of in vitro derived …

We know a great deal about the development of the mammalian embryo until the time that
the blastocyst implants into the uterus. With model organisms such as the mouse, we have …

The motivation for many reproductive biologists to study early developmental processes is
the specter of overpopulation. The figures are grim; for example, India is estimated to have a …

In vitro culture of whole mouse embryos enables the maintenance of growth and
morphogenesis of postimplantation embryos outside the uterine environment. This …

In vitro culture of mammalian embryos dates back at least as far as the work of Brachet in
Belgium in 1913 who cultured rabbit blastocysts (1). Early workers such as Lewis and …