Minocycline has been shown to be neuroprotective in various models of neurodegenerative
diseases. However, its potential in Huntington's disease (HD) models characterized by …

According to the recent controversy regarding the effects of minocycline in the R6/2
transgenic model of Huntington's disease (HD), this tetracycline has been re-evaluated in …

Minocycline has been shown to exert anti‐inflammatory effects underlying its putative
neuroprotective properties in the 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine (MPTP) …

Abstract Huntington's disease (HD), a relentlessly progressive neurodegenerative disorder,
is characterized by a clinical triad of psychiatric, cognitive and motor disturbances. The …

The combination effects of minocycline (MC), a second-generation tetracycline compound
and pyruvate (PY), a glycolysis end metabolite with antioxidant activity were investigated in …

Previous studies in rodent models of neurodegenerative disorders have demonstrated that
minocycline exerts neuroprotective effects unrelated to its antimicrobial action. The purpose …

Minocycline is broadly protective in neurologic disease models featuring cell death and is
being evaluated in clinical trials. We previously demonstrated that minocycline-mediated …

Huntington's disease (HD) is a devastating autosomal dominant disorder characterized by
progressive motor and neuropsychological symptoms. Evidence implicating the apoptotic …

Huntington's Disease (HD) is an inherited neurological disorder causing movement
impairment, personality changes, dementia, and premature death, for which there is …

Minocycline is an antibiotic with anti-inflammatory and antiapoptotic properties that prolongs
survival in a transgenic Huntington disease (HD) mouse model. In a double-blind …