T‐cell‐based immunological memory has the potential to provide the host with life‐long
protection against pathogen reexposure and thus offers tremendous promise for the design …

The developmental origins of memory T cells remain incompletely understood. During the
expansion phase of acute viral infection, we identified a distinct subset of virus-specific …

Memory for antigen is a defining feature of adaptive immunity. Antigen-specific lymphocyte
populations show an increase in number and function after antigen encounter and more …

In response to infection, antigen‐specific CD8+ T cells undergo massive expansion in
numbers, acquire effector mechanisms, and disseminate throughout the body. The …

CD8+ T cells play a key role in protecting the body against invading microorganisms. Their
capacity to control infection relies on the development of peripheral effector and memory T …

After the resolution of an immune response, antigen-specific memory T cells persist at many
sites in the body. The antigen-specific memory T-cell pool includes memory T cells that …

Immune protection and lasting memory are accomplished through the generation of
phenotypically and functionally distinct CD8 T cell subsets. Understanding how these …

While many aspects of memory T‐cell immunobiology have been characterized, we suggest
that we know only a fraction of the effector functions that CD4 T cells can bring to bear during …

The adaptive immune system has evolved a unique capacity to remember a pathogen
through the generation of memory T cells, which rapidly protect the host in the event of …

Resident memory CD8+ T (Trm) cells permanently reside in nonlymphoid tissues where they
act as a first line of defense against recurrent pathogens. How and when antigen …