Immune responses to infection are optimally designed to generate large numbers of effector
T cells while simultaneously minimizing the collateral damage of their potentially lethal …

Immunological memory is a fundamental hallmark of the adaptive immune responses and
one of the most relevant aspects of protective immunity. Our understanding of the processes …

Abstract Naive CD4+ and CD8+ T cells undergo unique developmental programs after
activation, resulting in the generation of effector and long-lived memory T cells. Recent …

During an infection, antigen‐specific CD8+ T cells undergo numerous cellular and
transcriptional changes as they develop from naive T cells into effector and memory cells …

A functional memory T cell pool is critical for resistance to pathogen reinfection.
Lymphopenia produces memory-like CD8+ T cells through homeostatic proliferation, and …

The functional roles of memory B and T lymphocytes underlie the phenomenal success of
prophylactic vaccinations, which have decreased morbidities and mortalities from infectious …

Memory CD8+ T cells were originally thought to exist as two populations (effector and
central memory). In recent years, a third population called resident memory T cells has been …

Memory T cells survive throughout the lifetime of an individual and are protective upon
recall. It is not clear how memory T cells can live so long. Here, we demonstrate that at the …

An important goal of vaccination strategies is to elicit long term, effective immunity. Therefore
it is imperative to define the parameters that regulate the development and preservation of …

Memory CD8+ T-cell development is defined by the expression of a specific set of memory
signature genes. Despite recent progress, many components of the transcriptional control of …