In response to infection, CD8+ T cells integrate multiple signals and undergo an exponential
increase in cell numbers. Simultaneously, a dynamic differentiation process occurs, resulting …

A critical component of vaccine design is to generate and maintain antigen‐specific memory
lymphocytes of sufficient quantity and quality to give the host life‐long protection against re …

Memory CD8 T cells provide durable protection against diverse intracellular pathogens and
can be broadly segregated into distinct circulating and tissue-resident populations …

T cell memory is a cornerstone of protective immunity, and is the key element in successful
vaccination. Upon encountering the relevant pathogen, memory T cells are thought to initiate …

The ability of circulating CD4+ T cells to retain memories of previous antigenic encounters is
a cardinal feature of the adaptive immune system. Over the past two decades, since the first …

Effective immunization induces the development of populations of robust effector
lymphocytes specific for the immunizing antigens. Amongst them are cytotoxic/CD8+ T …

Background The generation of long-lived memory T cells is critical for successful vaccination
but the factors controlling their differentiation are still poorly defined. We tested the …

Immunization in the absence of CD4+ T cell help results in defective CD8+ T cell memory,
deficient recall responses and diminished protective immunity. Here we investigated at what …

Naive T cells proliferate in response to lymphopenia and acquire the phenotypic and
functional qualities of memory T cells, providing enhanced protection against infection. How …

A fundamental property of the adaptive immune system is the ability to generate antigen-
specific memory, which protects against repeated infections with the same pathogens and …