Evidence for functionally important adenosine A2a receptors in the rat hippocampus

RA Cunha, B Johansson, I van der Ploeg, AM Sebastia… - Brain research, 1994 - Elsevier
Adenosine A 2a receptors are not confined to dopamine-rich areas of the brain, since
thermocycling analysis shows that adenosine A 2a receptor mRNA is expressed also in the …

Evidence for the presence of excitatory A2 adenosine receptors in the rat hippocampus

AM Sebastiao, JA Ribeiro - Neuroscience letters, 1992 - Elsevier
The A 2 adenosine receptor agonist, CGS 21680 in nanomolar concentrations, reversibly
increased in a concentration-dependent manner the amplitude of orthodromically-evoked …

Activation of hippocampal adenosine A3 receptors produces a desensitization of A1 receptor-mediated responses in rat hippocampus

TV Dunwiddie, L Diao, HO Kim, JL Jiang… - Journal of …, 1997 - Soc Neuroscience
The adenosine A3 receptor is expressed in brain, but the consequences of activation of this
receptor on electrophysiological activity are unknown. We have characterized the actions of …

Interaction between adenosine A1 and A2 receptor-mediated responses in the rat hippocampus in vitro

EM O'Kane, TW Stone - European journal of pharmacology, 1998 - Elsevier
Previous work has been carried out on the effects of adenosine on transmitter release and
on the excitability of postsynaptic neurones, but little is known about the effects of adenosine …

Cross Talk Between A1 and A2A Adenosine Receptors in the Hippocampus and Cortex of Young Adult and Old Rats

LV Lopes, RA Cunha… - Journal of …, 1999 - journals.physiology.org
Adenosine modulates synaptic transmission by acting on inhibitory A1 and facilitatory A2A
receptors, the densities of which are modified in aged animals. We investigated how A2A …

Transducing system operated by adenosine A2A receptors to facilitate acetylcholine release in the rat hippocampus

N Rebola, CR Oliveira, RA Cunha - European journal of pharmacology, 2002 - Elsevier
Although molecular biology studies indicate the presence of adenosine A2A receptors in the
rat hippocampus, the pharmacological characterization of adenosine A2A receptor binding …

Different synaptic and subsynaptic localization of adenosine A2A receptors in the hippocampus and striatum of the rat

N Rebola, PM Canas, CR Oliveira, RA Cunha - Neuroscience, 2005 - Elsevier
Adenosine A2A receptors are most abundant in the striatum where they control the
striatopallidal pathway thus controlling locomotion. Extra-striatal A2A receptors are …

High level of adenosine A1 receptor-like immunoreactivity in the CA2/CA3a region of the adult rat hippocampus

T Ochiishi, Y Saitoh, A Yukawa, M Saji, Y Ren, T Shirao… - Neuroscience, 1999 - Elsevier
We describe the immunocytochemical distribution of adenosine A1 receptors in the rat
hippocampus. Adenosine A1 receptor-like immunoreactivity was seen on the cell soma and …

Adenosine A1 and A2A receptors are co-expressed in pyramidal neurons and co-localized in glutamatergic nerve terminals of the rat hippocampus

N Rebola, RJ Rodrigues, LV Lopes, PJ Richardson… - Neuroscience, 2005 - Elsevier
Adenosine is a neuromodulator that controls neurotransmitter release through inhibitory A1
and facilitatory A2A receptors. Although both adenosine receptor-mediated inhibition and …

Adenosine A2A receptor facilitation of synaptic transmission in the CA1 area of the rat hippocampus requires protein kinase C but not protein kinase A activation

RA Cunha, JA Ribeiro - Neuroscience letters, 2000 - Elsevier
Adenosine is a neuromodulator in the hippocampus acting mainly via inhibitory A1 receptors
but also via facilitatory A2A receptors. We now investigated the transducing system operated …