Obesity is a disorder characterized by an excess accumulation of body fat resulting from a
mismatch between energy intake and expenditure. Incidence of obesity has increased …

Genome-wide association promises to enhance greatly our understanding of the genetic
basis of common obesity, although candidate gene studies will remain a valuable approach …

There is a genetic component to human obesity that accounts for 40% to 50% of the
variability in body weight status but that is lower among normal weight individuals (about …

The last few years have seen major advances in common non-syndromic obesity research,
much of it the result of genetic studies. This Review outlines the competing hypotheses …

Obesity is an important factor contributing to the global burden of morbidity and mortality. By
identifying obesity susceptibility genes, scientists aim to elucidate some of its aetiology …

The prevalence of obesity has tripled over the past four decades, imposing an enormous
burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset …

Obesity is a common complex trait that elevates the risk for various diseases, including type
2 diabetes and cardiovascular disease. A combination of environmental and genetic factors …

The genetic contribution to interindividual variation in common obesity has been estimated
at 40–70%. Yet, despite a relatively high heritability, the search for obesity susceptibility …

Candidate gene and genome-wide association studies have led to the discovery of nine loci
involved in Mendelian forms of obesity and 58 loci contributing to polygenic obesity. These …

Multiple biological, behavioural and genetic determinants or correlates of obesity have been
identified to date. Genome-wide association studies (GWAS) have contributed to the …