Segregation analysis of plasma lipoprotein (a) levels in pedigrees with molecularly defined familial hypercholesterolemia

Y Friedlander, E Leitersdorf - Genetic epidemiology, 1995 - Wiley Online Library
The role of genetic and environmental factors in determining the variability in plasma
lipoprotein (a)[Lp (a)] levels was investigated in 220 members of 14 families with familial …

Diverse effect of ethnicity on plasma lipoprotein [a] levels in heterozygote patients with familial hypercholesterolemia.

E Leitersdorf, Y Friedlander, JM Bard, JC Fruchart… - Journal of lipid …, 1991 - ASBMB
Plasma lipids, lipoproteins, and lipoprotein [a](Lp [a]) levels were determined in 216
members of 14 families with familial hypercholesterolemia (FH). Ninety-nine subjects …

Lipoprotein (a) in homozygous familial hypercholesterolemia

HG Kraft, A Lingenhel, FJ Raal… - … , and vascular biology, 2000 - Am Heart Assoc
Lipoprotein (a)[Lp (a)] is a quantitative genetic trait that in the general population is largely
controlled by 1 major locus—the locus for the apolipoprotein (a)[apo (a)] gene. Sibpair …

Genetics of the quantitative Lp (a) lipoprotein trait: III. Contribution of Lp (a) glycoprotein phenotypes to normal lipid variation

E Boerwinkle, HJ Menzel, HG Kraft, G Utermann - Human genetics, 1989 - Springer
Summary Apolipoprotein (a)[apo (a)] is a large serum glycoprotein with several genetically
determined isoforms differing in their apparent molecular weight. We determined the effects …

Lipoprotein (a): relation to other risk factors and genetic heritability. Results from a Dutch parent-twin study

DI Boomsma, A Kaptein, HJM Kempen, JAG Leuven… - Atherosclerosis, 1993 - Elsevier
We measured plasma levels of lipoprotein (a)(Lp (a)) in a sample of 152 Dutch adolescent
mono-and dizygotic twin pairs and their parents. The distribution of Lp (a) levels was …

Genetic variation in lipoprotein (a) levels in families enriched for coronary artery disease is determined almost entirely by the apolipoprotein (a) gene locus.

CA DeMeester, X Bu, RJ Gray, AJ Lusis… - American journal of …, 1995 - ncbi.nlm.nih.gov
Abstract Lipoprotein (a)(Lp [a]) is a cholesterol-rich lipoprotein resembling LDL but also
containing a large polypeptide designated apolipoprotein (a)(apo [a]). Its levels are highly …

Lp (a) levels and atherosclerotic vascular disease in a sample of patients with familial hypercholesterolemia sharing the same gene defect

R Carmena, S Lussier-Cacan, M Roy… - … , and vascular biology, 1996 - Am Heart Assoc
There is considerable variation in the severity of cardiovascular disease among patients with
familial hypercholesterolemia (FH). Some reports have suggested that plasma lipoprotein …

Lp (a) concentration and apo (a) isoform size. Relation to the presence of coronary artery disease in familial hypercholesterolemia.

JF Bowden, PH Pritchard, JS Hill… - … and Thrombosis: A …, 1994 - Am Heart Assoc
We studied the relation between the concentration of lipoprotein (a)[Lp (a)] in plasma,
apolipoprotein (a)[apo (a)] phenotype, and the clinical expression of coronary artery disease …

Apolipoprotein (a) gene accounts for greater than 90% of the variation in plasma lipoprotein (a) concentrations.

E Boerwinkle, CC Leffert, J Lin… - The Journal of …, 1992 - Am Soc Clin Investig
Plasma lipoprotein (a)[Lp (a)], a low density lipoprotein particle with an attached
apolipoprotein (a)[apo (a)], varies widely in concentration between individuals. These …

Serum lipoprotein (a) levels differ in different phenotypes of primary hyperlipoproteinemia

T Hiraga, M Okubo, T Kobayashi, K Nakanishi… - Metabolism, 1993 - Elsevier
Previous studies have indicated that serum lipoprotein (a)[Lp (a)] levels are mostly under
genetic control. We have attempted to determine whether serum Lp (a) levels differ in …