[引用][C] Genetic architecture of the atherogenic lipoprotein (a)

G Utermann, C Haibach, M Trommsdorff… - Annals of the New …, 1994 - Wiley Online Library
Lipoprotein (a)[Lp (a)] is a quantitative genetic trait in human plasma that is almost
unaffected by age, diet, or life-style. Thc distribution of Lp (a) plasma concentrations is …

Lipoprotein (a) serum concentration in familial combined hyperlipidemia

M Fonda, PG Da Col, R La Verde, C Battello… - Clinica chimica acta, 1993 - Elsevier
Abstract The lipoprotein (a)(Lp (a)) concentrations in serum were measured by an ELISA
technique in 53 subjects affected by familial combined hyperlipidemia (FCHL) and in 347 …

A study of the structural heterogeneity of low‐density lipoproteins in two patients homozygous for familial hypercholesterolaemia, one of phenotype E2/2

G Luc, MJ Chapman, JLDE GENNES… - European Journal of …, 1986 - Wiley Online Library
The structural heterogeneity of the low‐density lipoproteins (d 1· 019—1· 063 g ml‐1) in two
female patients homozygous for familial hypercholesterolaemia, one of phenotype E2/2, has …

Genetics of plasma lipoprotein (a) concentrations

E Boerwinkle - Current Opinion in Lipidology, 1992 - journals.lww.com
Abstract Lipoprotein (a)[Lp (a)] is a low-density-like lipoprotein with the addition of a Lp (a)-
specific protein, apolipoprotein (a)[apo (a)]. Plasma concentrations of Lp (a) are a risk factor …

Two-locus linkage analysis applied to putative quantitative trait loci for lipoprotein (a) levels

M Beekman, BT Heijmans, NG Martin… - Twin Research and …, 2003 - cambridge.org
Plasma levels of lipoprotein (a)—Lp (a)—are associated with cardiovascular risk (Danesh et
al., 2000) and were long believed to be influenced by the LPA locus on chromosome 6q27 …

Genetic basis for multimodal relationship between apolipoprotein (a) size and lipoprotein (a) concentration in Mexican-Americans

DL Rainwater - Atherosclerosis, 1995 - Elsevier
The reported general inverse relationship between apolipoprotein (a)(apo (a)) size and
plasma lipoprotein (a)(Lp (a)) concentrations was further characterized using 927 samples …

Genetic architecture and evolution of the lipoprotein (a) trait

G Utermann - Current opinion in lipidology, 1999 - journals.lww.com
Apolipoprotein (a) is coded by one of the most polymorphic genes known in humans. In
white and Asian populations variation in this gene is the major determinant of the plasma …

Apolipoprotein (a) genetic polymorphism and serum lipoprotein (a) concentration in patients with peripheral vascular disease

J Pedro-Botet, M Senti, T Auguet, X Nogués… - Atherosclerosis, 1993 - Elsevier
Abstract Serum lipoprotein (a)(Lp (a)) levels were measured in 89 men with peripheral
vascular disease (PVD) and 129 (100 male and 29 woman) healthy controls. Apolipoprotein …

Plasma Lp (a) values in familial hypercholesterolemia and its relation to coronary heart disease.

JT Real, JF Ascaso, FJ Chaves, S Tenes… - Nutrition, Metabolism …, 1999 - europepmc.org
Methods and results Ninety heterozygous FH patients and 41 non-FH relatives were
enrolled in a study to evaluate their plasma and lipoprotein cholesterol, as well as their …

Lipoprotein Lp (a) in homozygous familial hypercholesterolemia: density profile, particle heterogeneity and apolipoprotein (a) phenotype

HC Guo, J Chapman, E Bruckert, JP Farriaux… - Atherosclerosis, 1991 - Elsevier
Homozygous familial hypercholesterolemia (FH) is a genetic disorder featuring a functional
defect in cellular LDL receptors, marked elevation in circulating LDL concentrations, and …