The autonomic nervous system and hypertension

G Mancia, G Grassi - Circulation research, 2014 - Am Heart Assoc
Physiological studies have long documented the key role played by the autonomic nervous
system in modulating cardiovascular functions and in controlling blood pressure values …

Evidence for a critical role of the sympathetic nervous system in hypertension

G Grassi, VS Ram - Journal of the American Society of Hypertension, 2016 - Elsevier
Autonomic cardiovascular control is impaired in hypertension, leading to a reduction in the
parasympathetic tone and to an increase in the sympathetic influences to the heart and …

The 'neuroadrenergic hypothesis' in hypertension: current evidence

G Grassi, G Seravalle… - Experimental …, 2010 - Wiley Online Library
Data collected in experimental animals and in humans support the hypothesis that
sympathetic neural mechanisms are involved in the development and progression of …

Sympathetic neural activity in hypertension and related diseases

G Grassi - American journal of hypertension, 2010 - academic.oup.com
Background Several hemodynamic variables, such as blood pressure, vascular resistance,
cardiac output, and heart rate, are regulated, among others, by sympathetic cardiovascular …

Sympathetic activation in the pathogenesis of hypertension and progression of organ damage

G Mancia, G Grassi, C Giannattasio, G Seravalle - Hypertension, 1999 - Am Heart Assoc
Although animal models of hypertension have clearly shown that high blood pressure is
associated with and is probably caused by an increase in sympathetic cardiovascular …

Sympathetic nervous system and hypertension: New evidences

G Seravalle, G Grassi - Autonomic Neuroscience, 2022 - Elsevier
Evidences collected in the past few years have strengthened the concept that the
sympathetic nervous system plays a primary role in the development and progression of the …

The sympathetic control of blood pressure

PG Guyenet - Nature Reviews Neuroscience, 2006 - nature.com
Hypertension—the chronic elevation of blood pressure—is a major human health problem.
In most cases, the root cause of the disease remains unknown, but there is mounting …

Pathophysiology of essential hypertension: an update

T Saxena, AO Ali, M Saxena - Expert review of cardiovascular …, 2018 - Taylor & Francis
Introduction: Hypertension is caused by increased cardiac output and/or increased
peripheral resistance. Areas covered: The various mechanisms affecting cardiac …

Autonomic dysregulation in essential hypertension: insight from heart rate and arterial pressure variability

M Pagani, D Lucini - Autonomic Neuroscience, 2001 - Elsevier
Essential hypertension is the most prevalent cardiovascular disorder, affecting more than 50
million people in the USA. Hypertension-related mortality and morbidity figures have been …

Sympathetic activity, blood pressure variability and end organ damage in hypertension.

G Mancia, MD Rienzo, G Parati… - Journal of human …, 1997 - search.ebscohost.com
Animal studies have provided clearcut evidence that sympathetic factors are involved in the
development and maintenance of high blood pressure (BP). This also appears to be the …