Molecular mechanisms and pathways involved in bovine embryonic genome activation and their regulation by alternative in vivo and in vitro culture conditions

A Gad, M Hoelker, U Besenfelder… - Biology of …, 2012 - academic.oup.com
Understanding gene expression patterns in response to altered environmental conditions at
different time points of the preimplantation period would improve our knowledge on …

[HTML][HTML] Single-cell RNA sequencing reveals developmental heterogeneity of blastomeres during major genome activation in bovine embryos

I Lavagi, S Krebs, K Simmet, A Beck… - Scientific reports, 2018 - nature.com
Embryonic development is initially controlled by maternal RNAs and proteins stored in the
oocyte, until gene products gradually generated by the embryo itself take over. Major …

[HTML][HTML] Association between the morphokinetics of in-vitro-derived bovine embryos and the transcriptomic profile of the derived blastocysts

S Yaacobi-Artzi, D Kalo, Z Roth - Plos one, 2022 - journals.plos.org
The time-lapse system is a non-invasive method that enables a continuous evaluation
through embryo development. Here, we examined the association between the …

Genome activation in bovine embryos: review of the literature and new insights from RNA sequencing experiments

A Graf, S Krebs, M Heininen-Brown… - Animal reproduction …, 2014 - Elsevier
Maternal-to-embryonic transition (MET) is the period in early embryonic development when
maternal RNAs and proteins stored in the oocyte are gradually degraded and transcription …

[HTML][HTML] Developmental and molecular correlates of bovine preimplantation embryos

H Sagirkaya, M Misirlioglu, A Kaya, NL First… - …, 2006 - rep.bioscientifica.com
Expression of embryonic genes is altered in different culture conditions, which influence
developmental potential both during preimplantation and fetal development. The objective of …

Differential gene expression profile in bovine blastocysts resulting from hyperglycemia exposure during early cleavage stages

GLM Cagnone, I Dufort, C Vigneault… - Biology of …, 2012 - academic.oup.com
To understand the compromised survival of embryos derived from assisted reproductive
techniques, transcriptome survey of early embryonic development has shown the impact of …

Genome-wide expression profiling reveals distinct clusters of transcriptional regulation during bovine preimplantation development in vivo

WA Kues, S Sudheer, D Herrmann… - Proceedings of the …, 2008 - National Acad Sciences
Bovine embryos can be generated by in vitro fertilization or somatic nuclear transfer;
however, these differ from their in vivo counterparts in many aspects and exhibit a higher …

Dynamics of global transcriptome in bovine matured oocytes and preimplantation embryos

M Misirlioglu, GP Page, H Sagirkaya… - Proceedings of the …, 2006 - National Acad Sciences
Global activation of the embryonic genome is the most critical event in early mammalian
development. After fertilization, a rich supply of maternal proteins and RNAs support …

Fine mapping of genome activation in bovine embryos by RNA sequencing

A Graf, S Krebs, V Zakhartchenko… - Proceedings of the …, 2014 - National Acad Sciences
During maternal-to-embryonic transition control of embryonic development gradually
switches from maternal RNAs and proteins stored in the oocyte to gene products generated …

Large-scale transcriptional analysis of bovine embryo biopsies in relation to pregnancy success after transfer to recipients

A El-Sayed, M Hoelker, F Rings… - Physiological …, 2006 - journals.physiology.org
The purpose of this work is to address the relationship between transcriptional profile of
embryos and the pregnancy success based on gene expression analysis of blastocyst …