We have investigated the contribution of CD4 T cells to the optimal priming of functionally
robust memory CD8 T cell subsets. Intranasal infection of CD4 T cell-deficient (CD4−/−) mice …

Mechanisms for the generation of memory CD4 T cells and their delineation into diverse
subsets remain largely unknown. In this study, we demonstrate in two Ag systems, divergent …

The role of CD4 T cell help in primary and secondary CD8 T cell responses to infectious
pathogens remains incompletely defined. The primary CD8 T response to infections was …

Chronic infection results in continuous formation and exhaustion of effector CD8 T cells and
in failure of memory CD8 T cell development. Expression of CD70 and other molecules that …

An important goal of vaccination strategies is to elicit long term, effective immunity. Therefore
it is imperative to define the parameters that regulate the development and preservation of …

As memory CD8 T cells form during acute viral infection, several changes in gene
expression and function occur, but little is known about the control of this process. It was …

The role of CD4 T cells in providing help to CD8 T cells in primary and secondary responses
to infection remains controversial. Using recombinant strains of virus and bacteria …

Memory T cells can persist for extended periods in the absence of antigen, and long-term T
cell immunity is often seen after acute infections. Paradoxically, there have been …

CD27 interactions with its ligand, CD70, are thought to be necessary for optimal primary and
memory adaptive immune responses to a variety of pathogens. Thus far, all studies …

In this report we have inspected whether difficulties in controlling viral infections negatively
impacts the generation of CD127 high memory T cells. Using both MHC class I and II …