[图书][B] Reactive oxygen: its sources and significance in Alzheimer disease
G Perry, A Nunomura, AD Cash, MA Taddeo, K Hirai… - 2002 - Springer
Over the past decade, oxidative stress has been established as the earliest cytological
feature of Alzheimer disease and an attractive therapeutic target. The major challenges now …
feature of Alzheimer disease and an attractive therapeutic target. The major challenges now …
Alzheimer's disease and oxygen radicals: new insights
D Praticò - Biochemical pharmacology, 2002 - Elsevier
Alzheimer's disease (AD) is the most common form of neurodegenerative disease, with
dementia, in the elderly. In addition to the presence of senile plaques and neurofibrillary …
dementia, in the elderly. In addition to the presence of senile plaques and neurofibrillary …
Serial review: causes and consequences of oxidative stress in Alzheimer's disease
MA Smith, G Perry, BJ Tabner, S Turnbull… - Free radical biology & …, 2002 - academia.edu
Over the past decade, the study of oxidative stress in relation to the pathogenesis of
Alzheimer's and other neurodegenerative diseases has been transformed from an esoteric …
Alzheimer's and other neurodegenerative diseases has been transformed from an esoteric …
Signal transduction cascades associated with oxidative stress in Alzheimer's disease
RB Petersen, A Nunomura, H Lee… - Journal of …, 2007 - content.iospress.com
It has now been established through multiple lines of evidence that oxidative stress is an
early event in Alzheimer's disease, occurring prior to the canonical cytopathology. Thus …
early event in Alzheimer's disease, occurring prior to the canonical cytopathology. Thus …
Reactive oxygen species mediate cellular damage in Alzheimer disease
G Perry, RJ Castellani, K Hirai… - Journal of Alzheimer's …, 1998 - content.iospress.com
The two most striking features of Alzheimer disease are (i) the multitude of abnormalities
affecting essentially every system and (ii) the strict age dependence. Recent work suggests …
affecting essentially every system and (ii) the strict age dependence. Recent work suggests …
Oxidative stress signalling in Alzheimer's disease
Multiple lines of evidence demonstrate that oxidative stress is an early event in Alzheimer's
disease (AD), occurring prior to cytopathology, and therefore may play a key pathogenic role …
disease (AD), occurring prior to cytopathology, and therefore may play a key pathogenic role …
Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: beyond damage and response
In this review, we consider comparative aspects of the biology and pathology of oxygen
radicals in neurodegenerative disease and how these findings have influenced our concept …
radicals in neurodegenerative disease and how these findings have influenced our concept …
How important is oxidative damage? Lessons from Alzheimer's disease
Historically, efforts to understand oxidative status have focused on the concept of oxidative
stress, ie, the breaching of oxidant defenses with consequent detriment. By this definition …
stress, ie, the breaching of oxidant defenses with consequent detriment. By this definition …
Oxidative stress: The core pathogenesis and mechanism of Alzheimer's disease
As the number of patients with Alzheimer's disease (AD) increases, it brings great suffering
to their families and causes a heavy socioeconomic burden to society. A vast amount of …
to their families and causes a heavy socioeconomic burden to society. A vast amount of …
Oxidative stress hypothesis in Alzheimer's disease
WR Markesbery - Free radical biology and medicine, 1997 - Elsevier
The major hurdle in understanding Alzheimer's disease (AD) is a lack of knowledge about
the etiology and pathogenesis of selective neuron death. In recent years, considerable data …
the etiology and pathogenesis of selective neuron death. In recent years, considerable data …