The lung develops from a very simple outpouching of the foregut into a highly complex,
finely structured organ with multiple specialized cell types that are required for its normal …

Environmental disruptions during the course of lung development produce long-term
changes in lung structure and function that predispose towards adult lung disease, a …

Background Disruption of alveolar epithelial cell (AEC) differentiation is implicated in distal
lung diseases such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis …

Epigenetic mechanisms represent potential molecular routes which could bridge the gap
between genetic background and environmental risk factors contributing to the …

Perinatal insults, including intrauterine growth restriction, preterm birth, maternal exposure to
toxins, or dietary deficiencies produce deviations in the epigenome of lung cells. Occurrence …

Chronic respiratory diseases are a major cause of worldwide mortality and morbidity.
Although hereditary severe deficiency of α1 antitrypsin (A1AD) has been established to …

The lung begins as a simple outpouching of the foregut and develops by stages into a highly
complex organ, the proper function of which is essential to life for terrestrial mammals …

The human lung is a relatively quiescent organ in the normal healthy state but contains
stem/progenitor cells that contribute to normal tissue maintenance and either repair or …

The advent of high-throughput technologies has provided exceptional assistance for lung
scientists to discover novel genetic variants underlying the development and progression of …

The pathogenesis of chronic obstructive pulmonary disease remains elusive; investigators in
the field have struggled to decipher the cellular and molecular processes underlying chronic …