[HTML][HTML] Bladder cancer detection in urine using DNA methylation markers: a technical and prospective preclinical validation

AE Hentschel, IJ Beijert, J Bosschieter, PC Kauer… - Clinical …, 2022 - Springer
Background The development of accurate urinary biomarkers for non-invasive and cost-
effective detection of primary and recurrent bladder tumours is recognized as one of the …

A two-gene methylation signature for the diagnosis of bladder cancer in urine

J Bosschieter, JA Nieuwenhuijzen, A Hentschel… - …, 2019 - Taylor & Francis
Aim: To analyze the potential of 14 cancer-associated genes, including six miRNAs, for
bladder cancer (BC) diagnosis in urine. Patients & methods: DNA methylation levels of 14 …

[HTML][HTML] Comparative analysis of urine fractions for optimal bladder cancer detection using DNA methylation markers

AE Hentschel, JA Nieuwenhuijzen, J Bosschieter… - Cancers, 2020 - mdpi.com
DNA methylation analysis of full void urine and urine pellet seems promising for bladder
cancer (BC) detection and surveillance. Urinary cell-free DNA from urine supernatant is now …

A novel set of DNA methylation markers in urine sediments for sensitive/specific detection of bladder cancer

J Yu, T Zhu, Z Wang, H Zhang, Z Qian, H Xu, B Gao… - Clinical cancer …, 2007 - AACR
Purpose: This study aims to provide a better set of DNA methylation markers in urine
sediments for sensitive and specific detection of bladder cancer. Experimental Design: Fifty …

A noninvasive urine-based methylation biomarker panel to detect bladder cancer and discriminate cancer grade

T Hermanns, AJ Savio, E Olkhov-Mitsel, A Mari… - … Oncology: Seminars and …, 2020 - Elsevier
Background Highly sensitive and specific urinary biomarkers for the early detection of
bladder cancer (BC) to improve the performance of urinary cytology are needed. Objective …

[HTML][HTML] Urine cell-based DNA methylation classifier for monitoring bladder cancer

AG van der Heijden, L Mengual, M Ingelmo-Torres… - Clinical …, 2018 - Springer
Background Current standard methods used to detect and monitor bladder cancer (BC) are
invasive or have low sensitivity. This study aimed to develop a urine methylation biomarker …

Improved Noninvasive Bladder Cancer Diagnosis using Urine Sediments and Novel DNA Methylation Biomarker Panels.

K Wang, Y Tian, H Xu - Clinical Laboratory, 2016 - europepmc.org
Background Aberrant DNA methylation status early in carcinogenesis represents a potential
indicator of tumor detection. We would like to establish a DNA methylation biomarker panel …

[HTML][HTML] A urine-based DNA methylation assay to facilitate early detection and risk stratification of bladder cancer

W Ruan, X Chen, M Huang, H Wang, J Chen… - Clinical …, 2021 - Springer
Background Current non-invasive tests have limited sensitivities and lack capabilities of pre-
operative risk stratification for bladder cancer (BC) diagnosis. We aimed to develop and …

A panel of three markers hyper-and hypomethylated in urine sediments accurately predicts bladder cancer recurrence

SF Su, AL de Castro Abreu, Y Chihara, Y Tsai… - Clinical Cancer …, 2014 - AACR
Purpose: The high risk of recurrence after transurethral resection of bladder tumor of
nonmuscle invasive disease requires lifelong treatment and surveillance. Changes in DNA …

[HTML][HTML] Urine DNA methylation assay enables early detection and recurrence monitoring for bladder cancer

X Chen, J Zhang, W Ruan, M Huang… - The Journal of …, 2020 - Am Soc Clin Investig
BACKGROUND Current methods for the detection and surveillance of bladder cancer (BCa)
are often invasive and/or possess suboptimal sensitivity and specificity, especially in early …