[HTML][HTML] Bladder cancer detection in urine using DNA methylation markers: a technical and prospective preclinical validation
AE Hentschel, IJ Beijert, J Bosschieter, PC Kauer… - Clinical …, 2022 - Springer
Background The development of accurate urinary biomarkers for non-invasive and cost-
effective detection of primary and recurrent bladder tumours is recognized as one of the …
effective detection of primary and recurrent bladder tumours is recognized as one of the …
A two-gene methylation signature for the diagnosis of bladder cancer in urine
J Bosschieter, JA Nieuwenhuijzen, A Hentschel… - …, 2019 - Taylor & Francis
Aim: To analyze the potential of 14 cancer-associated genes, including six miRNAs, for
bladder cancer (BC) diagnosis in urine. Patients & methods: DNA methylation levels of 14 …
bladder cancer (BC) diagnosis in urine. Patients & methods: DNA methylation levels of 14 …
[HTML][HTML] Comparative analysis of urine fractions for optimal bladder cancer detection using DNA methylation markers
AE Hentschel, JA Nieuwenhuijzen, J Bosschieter… - Cancers, 2020 - mdpi.com
DNA methylation analysis of full void urine and urine pellet seems promising for bladder
cancer (BC) detection and surveillance. Urinary cell-free DNA from urine supernatant is now …
cancer (BC) detection and surveillance. Urinary cell-free DNA from urine supernatant is now …
A novel set of DNA methylation markers in urine sediments for sensitive/specific detection of bladder cancer
Purpose: This study aims to provide a better set of DNA methylation markers in urine
sediments for sensitive and specific detection of bladder cancer. Experimental Design: Fifty …
sediments for sensitive and specific detection of bladder cancer. Experimental Design: Fifty …
A noninvasive urine-based methylation biomarker panel to detect bladder cancer and discriminate cancer grade
T Hermanns, AJ Savio, E Olkhov-Mitsel, A Mari… - … Oncology: Seminars and …, 2020 - Elsevier
Background Highly sensitive and specific urinary biomarkers for the early detection of
bladder cancer (BC) to improve the performance of urinary cytology are needed. Objective …
bladder cancer (BC) to improve the performance of urinary cytology are needed. Objective …
[HTML][HTML] Urine cell-based DNA methylation classifier for monitoring bladder cancer
AG van der Heijden, L Mengual, M Ingelmo-Torres… - Clinical …, 2018 - Springer
Background Current standard methods used to detect and monitor bladder cancer (BC) are
invasive or have low sensitivity. This study aimed to develop a urine methylation biomarker …
invasive or have low sensitivity. This study aimed to develop a urine methylation biomarker …
Improved Noninvasive Bladder Cancer Diagnosis using Urine Sediments and Novel DNA Methylation Biomarker Panels.
K Wang, Y Tian, H Xu - Clinical Laboratory, 2016 - europepmc.org
Background Aberrant DNA methylation status early in carcinogenesis represents a potential
indicator of tumor detection. We would like to establish a DNA methylation biomarker panel …
indicator of tumor detection. We would like to establish a DNA methylation biomarker panel …
[HTML][HTML] A urine-based DNA methylation assay to facilitate early detection and risk stratification of bladder cancer
W Ruan, X Chen, M Huang, H Wang, J Chen… - Clinical …, 2021 - Springer
Background Current non-invasive tests have limited sensitivities and lack capabilities of pre-
operative risk stratification for bladder cancer (BC) diagnosis. We aimed to develop and …
operative risk stratification for bladder cancer (BC) diagnosis. We aimed to develop and …
A panel of three markers hyper-and hypomethylated in urine sediments accurately predicts bladder cancer recurrence
SF Su, AL de Castro Abreu, Y Chihara, Y Tsai… - Clinical Cancer …, 2014 - AACR
Purpose: The high risk of recurrence after transurethral resection of bladder tumor of
nonmuscle invasive disease requires lifelong treatment and surveillance. Changes in DNA …
nonmuscle invasive disease requires lifelong treatment and surveillance. Changes in DNA …
[HTML][HTML] Urine DNA methylation assay enables early detection and recurrence monitoring for bladder cancer
X Chen, J Zhang, W Ruan, M Huang… - The Journal of …, 2020 - Am Soc Clin Investig
BACKGROUND Current methods for the detection and surveillance of bladder cancer (BCa)
are often invasive and/or possess suboptimal sensitivity and specificity, especially in early …
are often invasive and/or possess suboptimal sensitivity and specificity, especially in early …
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