Hypoxia-inducible factor-1α (HIF-1α) 1 is a global transcriptional regulator of the hypoxic
response. Under normoxic conditions, HIF-1α is recognized by the von Hippel-Lindau tumor …

Stabilization of the hypoxia-inducible factor-1 (HIF-1) protein is essential for its role as a
regulator of gene expression under low oxygen conditions. Here, employing a novel …

In normoxic cells the hypoxia‐inducible factor‐1α (HIF‐1α) is rapidly degraded by the
ubiquitin‐proteasome pathway, and activation of HIF‐1α to a functional form requires protein …

Abstract Hypoxia-inducible factor (HIF)-1α is a transcription factor that plays a critical role in
regulating genes involved in erythropoiesis and angiogenesis. Recent evidence indicates …

Oxygen-dependent proteolysis is the primary means of regulating the hypoxia-inducible
factor (HIF) family of transcription factors. The alpha-subunit of HIF factor 1 (HIF-1) contains …

Abstract Hypoxia-inducible factor-1 (HIF-1) is a transcriptional complex that controls cellular
and systemic homeostatic responses to oxygen availability. HIF-1α is the oxygen-regulated …

The hypoxia-inducible factor 1α (HIF-1α) is the master regulator of the cellular response to
hypoxia. A key regulator of HIF-1α is von Hippel-Lindau protein (pVHL), which mediates the …

Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls
angiogenesis, erythropoiesis, and glycolysis via transcriptional activation of target genes …

HIF (hypoxia-inducible factor) is a transcription factor that plays a pivotal role in cellular
adaptation to changes in oxygen availability. In the presence of oxygen, HIF is targeted for …

Hypoxia and induction of hypoxia-inducible factors (HIF-1α and HIF-2α) is a hallmark of
many tumors. Under normal oxygen tension HIF-alpha subunits are rapidly degraded …