Microglia originate from erythromyeloid progenitors (EMPs) in the yolk sac and develop in
the forming CNS. Microglia are fundamental for the development and function of a healthy …

Microglia account for approximately 12% of the total cellular population in the mammalian
brain. While neurons and astrocytes are considered the major cell types of the nervous …

The pro-inflammatory immune response driven by microglia is a key contributor to the
pathogenesis of several neurodegenerative diseases. Though the research of microglia …

Microglia, the resident immune cells of the brain, are difficult to obtain in high numbers and
purity using currently available methods; to date, microglia for experimental research are …

The human brain is a complex, three‐dimensional structure. To better recapitulate brain
complexity, recent efforts have focused on the development of human‐specific midbrain …

Microglia are macrophages of the central nervous system (CNS) that continuously scrutinize
their environment for damage. They colonize the cephalic mesenchyme during …

Microglia are brain macrophages that emerge from early erythro-myeloid precursors in the
embryonic yolk sac and migrate to the brain mesenchyme before the blood brain barrier is …

Astrocyte reactivation has been discovered to be an important contributor to several
neurological diseases. In vitro models involving human astrocytes have the potential to …

Advancement in human induced pluripotent stem cell (iPSC) neuron and microglial
differentiation protocols allow for disease modeling using physiologically relevant cells …

Microglia are the primary immune cells of the central nervous system. However, recent data
indicate that microglia also contribute to diverse physiological and pathophysiological …