Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised …

MS Avidan, HR Maybrier, AB Abdallah, E Jacobsohn… - The Lancet, 2017 - thelancet.com
Background Delirium is a common and serious postoperative complication. Subanaesthetic
ketamine is often administered intraoperatively for postoperative analgesia, and some …

[HTML][HTML] Intraoperative ketamine for prevention of depressive symptoms after major surgery in older adults: an international, multicentre, double-blind, randomised …

GA Mashour, AB Abdallah, KO Pryor… - British journal of …, 2018 - Elsevier
Background Ketamine is a general anaesthetic with anti-depressant effects at
subanaesthetic doses. We hypothesised that intraoperative administration of ketamine …

Intraoperative ketamine administration to prevent delirium or postoperative cognitive dysfunction: A systematic review and meta‐analysis

F Hovaguimian, C Tschopp… - Acta …, 2018 - Wiley Online Library
Background Postoperative cognitive complications are associated with substantial morbidity
and mortality. Ketamine has been suggested to have neuroprotective effects in various …

Ketamine attenuates delirium after cardiac surgery with cardiopulmonary bypass

JA Hudetz, KM Patterson, Z Iqbal, SD Gandhi… - Journal of cardiothoracic …, 2009 - Elsevier
OBJECTIVE: To determine if ketamine attenuates postoperative delirium concomitant with
an anti-inflammatory effect in patients undergoing cardiac surgery using cardiopulmonary …

Efficacy and safety of perioperative application of ketamine on postoperative depression: a meta-analysis of randomized controlled studies

J Guo, D Qiu, H Gu, X Wang, K Hashimoto… - Molecular …, 2023 - nature.com
Ketamine, a commonly used general anesthetic, can produce rapid and sustained
antidepressant effect. However, the efficacy and safety of the perioperative application of …

[HTML][HTML] Ketamine vs. haloperidol for prevention of cognitive dysfunction and postoperative delirium: a phase IV multicentre randomised placebo-controlled double …

A Hollinger, CA Rüst, H Riegger, B Gysi, F Tran… - Journal of clinical …, 2021 - Elsevier
Study objective Delirium is frequently observed in the postoperative and intensive care unit
(ICU) population. Due to the multifactorial origin of delirium and according to international …

The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active-and …

H Bornemann-Cimenti, M Wejbora… - Minerva …, 2016 - europepmc.org
Background Evidence confirms that perioperative ketamine administration decreases opioid
usage. To reduce the risk for potential psychodysleptic side effects, however, ketamine …

Ketamine and postoperative pain–a quantitative systematic review of randomised trials

N Elia, MR Tramèr - Pain, 2005 - Elsevier
Ketamine, an N-methyl-d-aspartate receptor antagonist, is known to be analgesic and to
induce psychomimetic effects. Benefits and risks of ketamine for the control of postoperative …

Does intraoperative ketamine attenuate inflammatory reactivity following surgery? A systematic review and meta-analysis

O Dale, AA Somogyi, Y Li, T Sullivan… - Anesthesia & …, 2012 - journals.lww.com
BACKGROUND: Reports regarding the ability of the anesthetic drug ketamine to attenuate
the inflammatory response to surgery are conflicting. In this systematic review we examined …

The efficacy of peri‐operative interventions to decrease postoperative delirium in non‐cardiac surgery: a systematic review and meta‐analysis.

Z Moyce, RN Rodseth, BM Biccard - Anaesthesia, 2014 - Wiley Online Library
The purpose of this meta‐analysis was to determine the efficacy of peri‐operative
interventions in decreasing the incidence of postoperative delirium. An electronic search of …