EGFR-TKIs resistance via EGFR-independent signaling pathways
Q Liu, S Yu, W Zhao, S Qin, Q Chu, K Wu - Molecular cancer, 2018 - Springer
Tyrosine kinase inhibitors (TKIs)-treatments bring significant benefit for patients harboring
epidermal growth factor receptor (EGFR) mutations, especially for those with lung cancer …
epidermal growth factor receptor (EGFR) mutations, especially for those with lung cancer …
Mechanisms of resistance to epidermal growth factor receptor inhibitors and novel therapeutic strategies to overcome resistance in NSCLC patients
L Lin, TG Bivona - Chemotherapy research and practice, 2012 - Wiley Online Library
The epidermal growth factor receptor (EGFR) is a well‐characterized oncogene that is
frequently activated by somatic kinase domain mutations in non‐small cell lung cancer …
frequently activated by somatic kinase domain mutations in non‐small cell lung cancer …
New strategies in overcoming acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer
The management of non–small cell lung carcinoma (NSCLC) has been transformed by the
observation that lung adenocarcinomas harboring mutations in epidermal growth factor …
observation that lung adenocarcinomas harboring mutations in epidermal growth factor …
EGFR mutation mediates resistance to EGFR tyrosine kinase inhibitors in NSCLC: From molecular mechanisms to clinical research
RF Dong, ML Zhu, MM Liu, YT Xu, LL Yuan… - Pharmacological …, 2021 - Elsevier
With the development of precision medicine, molecular targeted therapy has been widely
used in the field of cancer, especially in non-small-cell lung cancer (NSCLC). Epidermal …
used in the field of cancer, especially in non-small-cell lung cancer (NSCLC). Epidermal …
[HTML][HTML] EGFR-TKI resistance in NSCLC patients: mechanisms and strategies
Y Lin, X Wang, H Jin - American journal of cancer research, 2014 - ncbi.nlm.nih.gov
The epidermal growth factor receptor (EGFR) is a kind of receptor tyrosine kinase (RTK) that
plays a critical role in the initiation and development of malignant tumors via modulating …
plays a critical role in the initiation and development of malignant tumors via modulating …
Drug combination approach to overcome resistance to EGFR tyrosine kinase inhibitors in lung cancer
The discovery of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) has
led to unprecedented clinical response in a subset of lung cancer patients carrying the …
led to unprecedented clinical response in a subset of lung cancer patients carrying the …
Molecular mechanisms of resistance in epidermal growth factor receptor-mutant lung adenocarcinomas
AB Cortot, PA Jänne - European Respiratory Review, 2014 - Eur Respiratory Soc
The discovery of epidermal growth factor receptor (EGFR) mutations in nonsmall cell lung
cancer (NSCLC) has allowed the identification of a subset of patients whose tumours are …
cancer (NSCLC) has allowed the identification of a subset of patients whose tumours are …
Resistance to TKIs in EGFR-mutated non-small cell lung cancer: from mechanisms to new therapeutic strategies
Simple Summary Resistance to tyrosine kinase inhibitors (TKIs) of the epidermal growth
factor receptor (EGFR) in advanced mutant non-small cell lung cancer (NSCLC) constitutes …
factor receptor (EGFR) in advanced mutant non-small cell lung cancer (NSCLC) constitutes …
[HTML][HTML] Mechanisms of resistance to EGFR tyrosine kinase inhibitors
L Huang, L Fu - Acta Pharmaceutica Sinica B, 2015 - Elsevier
Since the discovery that non-small cell lung cancer (NSCLC) is driven by epidermal growth
factor receptor (EGFR) mutations, the EGFR tyrosine kinase inhibitors (EGFR-TKIs, eg …
factor receptor (EGFR) mutations, the EGFR tyrosine kinase inhibitors (EGFR-TKIs, eg …
Recent updates on the resistance mechanisms to epidermal growth factor receptor tyrosine kinase inhibitors and resistance reversion strategies in lung cancer
SK Tripathi, K Pandey… - Medicinal Research …, 2020 - Wiley Online Library
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) have led to a
substantial improvement in the prognosis of lung cancer patients by explicitly targeting the …
substantial improvement in the prognosis of lung cancer patients by explicitly targeting the …
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