Limited tolerance towards folded elements during secretion of the autotransporter Hbp

WSP Jong, CM Ten Hagen‐Jongman… - Molecular …, 2007 - Wiley Online Library
Many virulence factors secreted by pathogenic Gram‐negative bacteria belong to the
autotransporter (AT) family. ATs consist of a passenger domain, which is the actual secreted …

Estimating the size of the active translocation pore of an autotransporter

A Saurí, CM ten Hagen-Jongman, P van Ulsen… - Journal of molecular …, 2012 - Elsevier
Autotransporters (ATs) are large virulence factors secreted by Gram-negative bacteria. The
passenger domain, carrying the virulence functions, is transported across the bacterial outer …

Autotransporter β-domains have a specific function in protein secretion beyond outer-membrane targeting

A Saurí, N Oreshkova, Z Soprova, WSP Jong… - Journal of molecular …, 2011 - Elsevier
Autotransporters (ATs) of Gram-negative bacteria contain an N-proximal passenger domain
that is transported to the extracellular milieu and a C-terminal β-domain that inserts into the …

Comparative analysis of the biochemical and functional properties of C-terminal domains of autotransporters

E Marín, G Bodelón, LA Fernández - Journal of bacteriology, 2010 - Am Soc Microbiol
Autotransporters (ATs) are the largest group of proteins secreted by Gram-negative bacteria
and include many virulence factors from human pathogens. ATs are synthesized as large …

Structures and functions of autotransporter proteins in microbial pathogens

I Benz, MA Schmidt - International Journal of Medical Microbiology, 2011 - Elsevier
Since their discovery more than 20 years ago the autotransporter protein superfamily has
been growing continuously and currently represents the largest protein family in …

ATP-independent control of autotransporter virulence protein transport via the folding properties of the secreted protein

JP Renn, M Junker, RN Besingi, E Braselmann… - Chemistry & Biology, 2012 - cell.com
Autotransporter (AT) proteins are the largest class of extracellular virulence proteins
secreted from Gram-negative bacteria. The mechanism by which AT proteins cross the …

[HTML][HTML] Autotransporter secretion: varying on a theme

J Grijpstra, J Arenas, L Rutten, J Tommassen - Research in microbiology, 2013 - Elsevier
Autotransporters are widely distributed among Gram-negative bacteria. They can have a
large variety of functions and many of them have a role in virulence. They are synthesized as …

Interaction of an autotransporter passenger domain with BamA during its translocation across the bacterial outer membrane

R Ieva, HD Bernstein - … of the National Academy of Sciences, 2009 - National Acad Sciences
Autotransporters are a superfamily of virulence factors produced by Gram-negative bacteria
consisting of a large N-terminal extracellular domain (“passenger domain”) and a C-terminal …

Structural tolerance of bacterial autotransporters for folded passenger protein domains

E Veiga, V De Lorenzo… - Molecular microbiology, 2004 - Wiley Online Library
In this report we investigate the capacity of bacterial autotransporters (AT) to translocate
folded protein domains across the outer membrane (OM). Polypeptides belonging to the AT …

Secretion of a bacterial virulence factor is driven by the folding of a C-terminal segment

JH Peterson, P Tian, R Ieva, N Dautin… - Proceedings of the …, 2010 - National Acad Sciences
Autotransporters are bacterial virulence factors consisting of an N-terminal “passenger
domain” that is secreted in a C-to-N-terminal direction and a C-terminal “β domain” that …