Atrial fibrillation (AF) is the most prevalent sustained arrhythmia. As the most important risk
factor for embolic stroke, AF is associated with a high morbidity and mortality. Despite …

Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia in the clinical
setting. It is associated with substantial cardiovascular morbidity and mortality. Recent …

During atrial fibrillation (AF) intracellular Ca2+ signaling in atrial myocytes changes
substantially. This 'remodeled'intracellular Ca2+ homeostasis plays an important role in the …

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and its prevalence is
increasing with the ageing of the population. Presently available treatment options are far …

Subcellular calcium signalling silencing is a novel and distinct cellular and molecular
adaptive response to rapid cardiac activation. Calcium signalling silencing develops during …

Atrial electrical and structural alterations (remodeling) have emerged as key elements in the
development of the atrial fibrillation (AF) substrate. Evidence points to abnormalities in …

Atrial fibrillation (AF) is the most common cardiac arrhythmia with a substantial impact on
morbidity and mortality. Antiarrhythmic drugs play a major role in rhythm-control therapy of …

Both, the decreased L-type Ca2+ current (ICa, L) density and increased spontaneous Ca2+
release from the sarcoplasmic reticulum (SR), have been associated with atrial fibrillation …

Atrial fibrillation (AF) is commonly associated with heart failure. A bidirectional relationship
exists between the two—AF exacerbates heart failure causing a significant increase in heart …

Atrial fibrillation (AF) is the most frequently encountered clinical arrhythmia and is associated
with increased morbidity and mortality. Ectopic activity and reentry are considered major …