Cholesterol-induced conformational change in the sphingomyelin headgroup

S Hanashima, K Murakami, M Yura, Y Yano… - Biophysical …, 2019 - cell.com
Sphingomyelin (SM) and cholesterol (Cho) are the important lipids for the formation of
biologically functional membrane domains, lipid rafts. However, the interaction between Cho …

Effect of sphingomyelin headgroup size on molecular properties and interactions with cholesterol

A Björkbom, T Róg, K Kaszuba, M Kurita… - Biophysical journal, 2010 - cell.com
Sphingomyelins (SMs) and sterols are important constituents of the plasma membrane and
have also been identified as major lipid components in membrane rafts. Using SM analogs …

Orientation and order of the amide group of sphingomyelin in bilayers determined by solid-state NMR

N Matsumori, T Yamaguchi, Y Maeta, M Murata - Biophysical Journal, 2015 - cell.com
Sphingomyelin (SM) and cholesterol (Chol) are considered essential for the formation of
lipid rafts; however, the types of molecular interactions involved in this process, such as …

Impact of acyl chain mismatch on the formation and properties of sphingomyelin-cholesterol domains

TKM Nyholm, O Engberg, V Hautala, H Tsuchikawa… - Biophysical …, 2019 - cell.com
Lateral segregation and the formation of lateral domains are well-known phenomena in
ternary lipid bilayers composed of an unsaturated (low gel-to-liquid phase transition …

Cholesterol-sphingomyelin interactions: a molecular dynamics simulation study

T Róg, M Pasenkiewicz-Gierula - Biophysical Journal, 2006 - cell.com
Abstract Stearoylsphingomyelin (SSM) bilayers containing 0, 22, and 50mol% cholesterol
(Chol) and a pentadecanoylstearoylphosphatidylcholine (15SPC) bilayer containing …

N-nervonoylsphingomyelin (C24: 1) prevents lateral heterogeneity in cholesterol-containing membranes

S Maté, JV Busto, AB García-Arribas, J Sot… - Biophysical journal, 2014 - cell.com
This study was conducted to explore how the nature of the acyl chains of sphingomyelin
(SM) influence its lateral distribution in the ternary lipid mixture SM/cholesterol/1, 2-dioleoyl …

Sphingomyelins and ent-sphingomyelins form homophilic nano-subdomains within liquid ordered domains

Y Yano, S Hanashima, H Tsuchikawa, T Yasuda… - Biophysical journal, 2020 - cell.com
Sphingomyelin (SM), a major component of small domains (or lipid rafts) in mammalian cell
membranes, forms a liquid-ordered phase in the presence of cholesterol (Cho). However …

β-Glucosylation of cholesterol reduces sterol-sphingomyelin interactions

S Hanashima, N Fukuda, R Malabed, M Murata… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Abstract Cholesteryl-β-D-glucoside (ChoGlc) is a mammalian glycolipid that is expressed in
brain tissue. The effects of glucosylation on the ordering and lipid interactions of cholesterol …

[HTML][HTML] N-and O-methylation of sphingomyelin markedly affects its membrane properties and interactions with cholesterol

A Björkbom, T Róg, P Kankaanpää, D Lindroos… - … et Biophysica Acta (BBA …, 2011 - Elsevier
We have prepared palmitoyl sphingomyelin (PSM) analogs in which either the 2-NH was
methylated to NMe, the 3-OH was methylated to OMe, or both were methylated …

Sphingomyelin stereoisomers reveal that homophilic interactions cause nanodomain formation

Y Yano, S Hanashima, T Yasuda, H Tsuchikawa… - Biophysical journal, 2018 - cell.com
Sphingomyelin is an abundant lipid in some cellular membrane domains, such as lipid rafts.
Hydrogen bonding and hydrophobic interactions of the lipid with surrounding components …