Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney
The integration of single cell transcriptome and chromatin accessibility datasets enables a
deeper understanding of cell heterogeneity. We performed single nucleus ATAC (snATAC …
deeper understanding of cell heterogeneity. We performed single nucleus ATAC (snATAC …
[HTML][HTML] Understanding the kidney one cell at a time
A revolution in cellular measurement technology is underway. Whereas prior studies have
been able to analyze only the averaged outputs from renal tissue, we now can accurately …
been able to analyze only the averaged outputs from renal tissue, we now can accurately …
An atlas of healthy and injured cell states and niches in the human kidney
Understanding kidney disease relies on defining the complexity of cell types and states, their
associated molecular profiles and interactions within tissue neighbourhoods. Here we …
associated molecular profiles and interactions within tissue neighbourhoods. Here we …
Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets
Determining the epigenetic program that generates unique cell types in the kidney is critical
for understanding cell-type heterogeneity during tissue homeostasis and injury response …
for understanding cell-type heterogeneity during tissue homeostasis and injury response …
Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression
Kidneys are intricate three-dimensional structures in the body, yet the spatial and molecular
principles of kidney health and disease remain inadequately understood. We generated …
principles of kidney health and disease remain inadequately understood. We generated …
Targeted single-cell RNA-seq identifies minority cell types of kidney distal nephron
L Chen, CL Chou, MA Knepper - Journal of the American Society …, 2021 - journals.lww.com
Background Proximal tubule cells dominate the kidney parenchyma numerically, although
less abundant cell types of the distal nephron have disproportionate roles in water and …
less abundant cell types of the distal nephron have disproportionate roles in water and …
Mapping the human kidney using single-cell genomics
F Schreibing, R Kramann - Nature Reviews Nephrology, 2022 - nature.com
The field of single-cell genomics and spatial technologies is rapidly evolving and has
already provided unprecedented insights into complex tissues. Major advances have been …
already provided unprecedented insights into complex tissues. Major advances have been …
[HTML][HTML] Single-cell profiling reveals sex, lineage, and regional diversity in the mouse kidney
A Ransick, NO Lindström, J Liu, Q Zhu, JJ Guo… - Developmental cell, 2019 - cell.com
Chronic kidney disease affects 10% of the population with notable differences in ethnic and
sex-related susceptibility to kidney injury and disease. Kidney dysfunction leads to …
sex-related susceptibility to kidney injury and disease. Kidney dysfunction leads to …
Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes
Molecular characterization of the individual cell types in human kidney as well as model
organisms are critical in defining organ function and understanding translational aspects of …
organisms are critical in defining organ function and understanding translational aspects of …
High resolution spatial profiling of kidney injury and repair using RNA hybridization-based in situ sequencing
H Wu, EE Dixon, Q Xuanyuan, J Guo… - Nature …, 2024 - nature.com
Emerging spatially resolved transcriptomics technologies allow for the measurement of gene
expression in situ at cellular resolution. We apply direct RNA hybridization-based in situ …
expression in situ at cellular resolution. We apply direct RNA hybridization-based in situ …