Genetic and comparative mapping of genes dysregulated in mouse hearts lacking the Hand2 transcription factor gene
MP Villanueva, AR Aiyer, S Muller, MT Pletcher, X Liu… - Genomics, 2002 - Elsevier
The helix-loop-helix transcription factor HAND2 plays a vital role in the development of the
heart, limb, facies, and other neural crest-derived structures. We used differential display …
heart, limb, facies, and other neural crest-derived structures. We used differential display …
The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner
DG McFadden, AC Barbosa, JA Richardson… - 2005 - journals.biologists.com
The basic helix-loop-helix transcription factors Hand1 and Hand2 display dynamic and
spatially restricted expression patterns in the developing heart. Mice that lack Hand2 die at …
spatially restricted expression patterns in the developing heart. Mice that lack Hand2 die at …
DNA binding-dependent and-independent functions of the Hand2 transcription factor during mouse embryogenesis
N Liu, AC Barbosa, SL Chapman, S Bezprozvannaya… - 2009 - journals.biologists.com
The basic helix-loop-helix (bHLH) transcription factor Hand2 is required for growth and
development of the heart, branchial arches and limb buds. To determine whether DNA …
development of the heart, branchial arches and limb buds. To determine whether DNA …
Gene Replacement Strategies to Test the Functional Redundancy of Basic Helix–Loop–Helix Transcription Factor
AB Firulli, BA Firulli, J Wang, RH Rogers… - Pediatric cardiology, 2010 - Springer
Basic helix–loop–helix (bHLH) transcription factors control developmental decisions for a
wide range of embryonic cell types. Hand1 and Hand2 are closely related bHLH proteins …
wide range of embryonic cell types. Hand1 and Hand2 are closely related bHLH proteins …
Hand factors as regulators of cardiac morphogenesis and implications for congenital heart defects
JW Vincentz, RM Barnes… - Birth Defects Research Part …, 2011 - Wiley Online Library
Almost 15 years of careful study have established the related basic Helix‐Loop‐Helix
(bHLH) transcription factors Hand1 and Hand2 as critical for heart development across …
(bHLH) transcription factors Hand1 and Hand2 as critical for heart development across …
Analysis of the Hand1 cell lineage reveals novel contributions to cardiovascular, neural crest, extra‐embryonic, and lateral mesoderm derivatives
Abstract The basic Helix‐Loop‐Helix (bHLH) transcription factors Hand1 and Hand2 play
critical roles in the development of multiple organ systems during embryogenesis. The …
critical roles in the development of multiple organ systems during embryogenesis. The …
Analysis of a Hand1 hypomorphic allele reveals a critical threshold for embryonic viability
BA Firulli, DP McConville, JS Byers III… - Developmental …, 2010 - Wiley Online Library
Loss‐of‐function analysis of the basic helix–loop–helix (bHLH) transcription factor Hand1
indicates critical roles in development. In an effort to generate a Hand1 cDNA knock‐in …
indicates critical roles in development. In an effort to generate a Hand1 cDNA knock‐in …
A HANDful of questions: the molecular biology of the heart and neural crest derivatives (HAND)-subclass of basic helix–loop–helix transcription factors
AB Firulli - Gene, 2003 - Elsevier
The HAND subclass of basic Helix–loop–helix factors is comprised of two members HAND1
and HAND2. HAND genes are present within the genomes of organisms ranging from flies …
and HAND2. HAND genes are present within the genomes of organisms ranging from flies …
Early exclusion of hand1-deficient cells from distinct regions of the left ventricular myocardium in chimeric mouse embryos
The basic helix-loop-helix transcription factor gene Hand1 has been implicated in
development of the heart. However, the early lethality of Hand1-null mutant mouse embryos …
development of the heart. However, the early lethality of Hand1-null mutant mouse embryos …
[HTML][HTML] MEF2-dependent recruitment of the HAND1 transcription factor results in synergistic activation of target promoters
S Morin, G Pozzulo, L Robitaille, J Cross… - Journal of Biological …, 2005 - ASBMB
HAND proteins are tissue-restricted members of the basic helix-loop-helix transcription
factor family that play critical roles in cell differentiation and organogenesis including …
factor family that play critical roles in cell differentiation and organogenesis including …