The STAT3 story has almost 30 years of evolving history. First identified in 1994 as a pro-
inflammatory transcription factor, Signal Transducer and Activator of Transcription 3 (STAT3) …

The transcriptional regulator STAT3 has key roles in vertebrate development and mature
tissue function including control of inflammation and immunity. Mutations in human STAT3 …

Highlights•Inborn errors of human STAT1 immunity causes 4 types of inborn errors of
immunities with diverse nature of variants and mode of inheritance.•The co-existence of loss …

Background Lymphocyte differentiation is regulated by coordinated actions of cytokines and
signaling pathways. IL-21 activates STAT1, STAT3, and STAT5 and is fundamental for the …

Recent advances in genetics and technology have led to breakthroughs in understanding
the genes that predispose individuals to autoimmune diseases. A common haplotype of the …

The discovery of new gain-of-function mutations in STAT3, as well as new studies among
patients with loss-of-function mutations, expand the understanding of the pathophysiology of …

The Signal Transducer and Activator of Transcription (STAT)-5 proteins are required in
immune regulation and homeostasis and play a crucial role in the development and function …

The signal transducer and activator of transcription (STAT) 5b is a universal transcription
factor that plays key biological roles in allergic diseases, immunodeficiencies …

Signal transducer and activator of transcription 4 (STAT4) is a central mediator in generating
inflammation during protective immune responses and immune-mediated diseases. In the 8 …

Introduction: STAT4, which acts as the major signaling transducing STATs in response to IL-
12, is a central mediator in generating inflammation during protective immune responses …