Metabolic diseases including type 2 diabetes are associated with meta-inflammation. β-Cell
failure is a major component of the pathogenesis of type 2 diabetes. It is now well …

Evidence in support of the concept of local pancreatic islet inflammation as a mechanism of
β cell failure in type 2 diabetes is accumulating. Observations in human islets from type 2 …

In the past decade, islet inflammation has emerged as a contributor to the loss of functional β
cell mass in both type 1 (T1D) and type 2 diabetes (T2D). Evidence supports the idea that …

The finding of islet inflammation in type 2 diabetes (T2D) and its involvement in β cell
dysfunction has further highlighted the significance of inflammation in metabolic diseases …

Inflammation plays an important role in the destruction of pancreatic islet β-cells that leads to
type I diabetes. This involves infiltration of T-cells and macrophages into the islets and local …

Type 2 diabetes (T2D) is characterized by insulin resistance and impaired insulin secretion
from pancreatic β‐cells. Inflammatory cytokines, including tumour necrosis factor‐α (TNF‐α) …

Islets produce a variety of cytokines and chemokines in response to physiologic and
pathologic stimulation by nutrients. The cellular source of these inflammatory mediators …

Decreases in both mass and secretory function of insulin-producing β-cells contribute to the
pathophysiology of type 2 diabetes. The histology of islets from patients with type 2 diabetes …

Chronic, unresolved tissue inflammation is a well-described feature of obesity, type 2
diabetes mellitus (T2DM) and other insulin-resistant states. In this context, adipose tissue …

The role of the immune system is to restore functionality in response to stress. Increasing
evidence shows that this function is not limited to insults by infection or injury and plays a …