The extent to which the progeny of one primary memory CD8 T cell differs from the progeny
of one naive CD8 T cell of the same specificity remains an unresolved question. To explore …

The generation of effective adaptive T-cell memory is a cardinal feature of the adaptive
immune system. The establishment of protective T-cell immunity requires the differentiation …

The immune system has evolved by continuously increasing its complexity to provide the
host with an advantage over infectious agents. The development of immunological memory …

Clearance of primary infection often leads to the development of highly functional memory T
cells capable of rapid and long-lasting protective immunity. By contrast, chronic infections …

Both CD4+ T cell help and IL-2 have been postulated to “program” activated CD8+ T cells for
memory cell development. However, the linkage between these two signals has not been …

Abstract C D8 T-cell responses play an important role in protection against intracellular
pathogens. Memory CD8 T cells mediate rapid clearance of pathogens upon secondary …

An important goal of vaccination strategies is to elicit long term, effective immunity. Therefore
it is imperative to define the parameters that regulate the development and preservation of …

Immunization in the absence of CD4+ T cell help results in defective CD8+ T cell memory,
deficient recall responses and diminished protective immunity. Here we investigated at what …

In response to primary Ag contact, naive mouse CD8+ T cells undergo clonal expansion and
differentiate into effector T cells. After pathogen clearance, most effector T cells die, and only …

Recent studies suggest that memory T-cell differentiation continues for weeks or months
following antigen clearance, although commitment to the memory lineage occurs during the …